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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
NSC-324360
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
69839-83-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥800.0 |
| 规格： | 25 mg | 产品价格： | ￥1700.0 |
| 规格： | 50 mg | 产品价格： | ￥2600.0 |
| 规格： | 100 mg | 产品价格： | ￥4000.0 |
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Didox
CAS No. : 69839-83-4
MCE 国际站：Didox
产品活性：Didox (NSC-324360) 是一种合成的核糖核苷酸还原酶 (ribonucleotide reductase, RR) 抑制剂。
研究领域：Cell Cycle/DNA Damage
作用靶点：DNA/RNA Synthesis
In Vitro: Didox (NSC-324360) suppresses LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α, after 24 h of treatment. Treatment with Didox also suppresses the secretion of nitric oxide (NO), IL-6, and IL-10. Using mitochondrial dehydrogenase activity as a measure of cytotoxicity, the effects of Didox on cellular respiration in RAW264.7 are examined over a range of concentrations for 24 h. Cells exposures to 200 μM and below Didox, with and without LPS, do not exhibit significant cellular toxicity. Didox (NSC-324360) is active against all human and murine acute myeloid leukemia (AML) lines tested with IC50 values in the low micromolar range (mean IC50 37 µM [range 25.89-52.70 µM]).
In Vivo: Once engraftment is established by bioluminescent imaging, the animals receive daily administrations of Didox at 425 mg/kg via IP injection over 5 days. Didox (NSC-324360) treatment significantly reduces leukemic burden compared to vehicle treated controls (p=0.0026 and p=0.0342). More importantly, Didox (NSC-324360) provides a significant survival benefit (p<0.0001 and p=0.0094).
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