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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Roc-A
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
84573-16-0
- 规格：
10 mM * 1 mL/500 μg/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥5672.0 |
|---|---|---|---|
| 规格： | 500 μg | 产品价格： | ￥1280.0 |
| 规格： | 1 mg | 产品价格： | ￥2050.0 |
| 规格： | 5 mg | 产品价格： | ￥5100.0 |
| 规格： | 10 mg | 产品价格： | ￥8700.0 |
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Rocaglamide
CAS No. : 84573-16-0
MCE 国际站：Rocaglamide
产品活性：Rocaglamide (Roc-A) 是从楝科植物中分离出来，可用于咳嗽，受伤，哮喘和炎症性皮肤病。Rocaglamide 是 T 细胞中一种有效的 NF-κB 活化抑制剂。Rocaglamide 是一种有效的选择性热休克因子 1 (HSF1) 活化抑制剂，IC50 约为 50 nM。Rocaglamide 还抑制翻译起始因子 eIF4A 的功能。Rocaglamide 还具有抗癌特性。
研究领域：NF-κB | Metabolic Enzyme/Protease | Cell Cycle/DNA Damage
作用靶点：NF-κB | HSP | Eukaryotic Initiation Factor (eIF)
In Vitro: Rocaglamide enhances TRAIL-induced apoptosis in resistant HCC cells. Treatment with Rocaglamide alone leads to apoptosis in 9% HepG2 and 11% Huh-7 cells and treatment with TRAIL induces apoptosis in 16% HepG2 and 17% Huh-7 cells. However, the combination of Rocaglamide and TRAIL induces apoptosis in 55% HepG2 and 57% Huh-7 cells, which is evidently more than an additive effect. A similar result is obtained by measurement of cell viability using crystal violet staining. Rocaglamide has the potential to sensitize highly chemoresistant HepG2 and Huh-7 cells to TRAIL-based therapy.
In Vivo: Tumor volumes in the Rocaglamide-treated group are 45±12% compared with the control group. Rocaglamide significantly suppresses tumor growth compared with that in the control group. Treatment with Rocaglamide does not lead to any reduction in body weight and no apparent signs of toxicity are observed in the mice during the treatment, suggesting that Rocaglamide is generally tolerated well.
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