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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
537034-17-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥251.0 |
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥900.0 |
| 规格： | 25 mg | 产品价格： | ￥1600.0 |
| 规格： | 50 mg | 产品价格： | ￥2500.0 |
| 规格： | 100 mg | 产品价格： | ￥4000.0 |
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BML-210
CAS No. : 537034-17-6
MCE 国际站：BML-210
产品活性：BML-210 是一种有效的 HDAC 抑制剂。BML-210 可以抑制 HDAC4-VP16 驱动的报告信号，IC50 为 ~5 µM。BML-210 对 HDAC4:MEF2 交互具有特定的破坏性影响。BML-210 导致 G0/G1 期增加。BML-210 诱导细胞凋亡，并在小鼠原位乳腺肿瘤中显示出抗肿瘤活性。
研究领域：Cell Cycle/DNA Damage | Epigenetics | Apoptosis
In Vitro: BML-210 (10, 20 μM; 24, 48 hours) inhibits cell proliferation and growth inhibition of NB4 cells.
BML-210 (10, 20 μM; 24, 48 hours) causes a decrease in the proportion of NB4 cells in the S phase and an increase in the G0/G1 phase.
BML-210 (10, 20 μM; 24, 48 hours) causes cytotoxic effects on NB4 cells at 20 μM. BML-210 at a dose of 10 μM induces apoptotic cell death.
BML-210 (10, 20 μM; 24, 48 hours) inhibits HDAC Expression and Activity in NB4 Cells.
BML-210 (1.0 μM; for 48 h) causes higher expression levels differential expressed genes (DEGs) in mouse EO771 cells.
BML-210 does not reduce the expression of HDAC4-VP16.
In Vivo: BML-210 (20 mg/kg; IP; three times per week for two weeks) notably suppresses the tumour growth and weight. BML-210 has no effect on tumour growth and weight in the immune-deficient nude (Nu/J) mice.
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