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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
NCH-51
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
848354-66-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1529.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥560.0 |
| 规格： | 5 mg | 产品价格： | ￥1780.0 |
| 规格： | 10 mg | 产品价格： | ￥2450.0 |
| 规格： | 25 mg | 产品价格： | ￥3725.0 |
| 规格： | 50 mg | 产品价格： | ￥5525.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
PTACH
CAS No. : 848354-66-5
MCE 国际站：PTACH
产品活性：PTACH (NCH-51) 是一种有效的 HDAC 抑制剂，对 HDAC1，HDAC4 和 HDAC6 的 IC50 分别为 48 nM，32 nM 和 41 nM。PTACH 对多种癌细胞具有强大的生长抑制作用 (EC50 为 1.1-9.1 µM)。
研究领域：Cell Cycle/DNA Damage | Epigenetics | Anti-infection
In Vitro: PTACH (compound 51) treatment elevates the levels of acetylated histone H4 and p21WAF1/CIP1 in a dose-dependent manner.
In cancer cell growth inhibition assay, PTACH (compound 51) shows strong activity. PTACH inhibits various cancer cells with EC50 values of 2.3 μM, 9.1 μM, 3.0 μM, 2.6 μM, 1.1 μM, 4.5 μM, 2.4 μM, 5.0 μM, and 4.5 μM for MDA-MB-231, SNB-78, HCT116, NCI-H226, LOX-IMVI, SK-OV-3, RXF-631L, St-4, and DU-145 cells, respectively.
PTACH (NCH-51) augments the HIV-1 production in latently infected OM10.1 cells and such reactivation is associated with a loss of HDAC1 occupancy and subsequent hyperacetylation of histones in nuc-1 at the HIV-1 promoter.
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