新型冠状病毒(SARS-CoV-2)已成为国际关注的突发公共卫生事件,截至目前,全球已累计确诊病例超过700万例,死亡累计超过40万人。攻关新冠病毒的入侵机制,寻找潜在的治疗性药物,抗体等应对手段,全球科学家正在通力合作,寻找突破。
从中,我们对Strep-tag 及其相关技术在新冠病毒研究中的应用进行了总结,同时我们也为相关的研究工具均推出了优惠活动,以更好的为各课题组的研究助力。
文献总结:
Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., . . . Krogan, N. J. (2020). A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. doi:10.1038/s41586-020-2286-9
Long, Q. X., Liu, B. Z., Deng, H. J., Wu, G. C., Deng, K., Chen, Y. K., . . . Huang, A. L. (2020). Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat Med. doi:10.1038/s41591-020-0897-1
Wang, C., Li, W., Drabek, D., Okba, N. M. A., van Haperen, R., Osterhaus, A., . . . Bosch, B. J. (2020). A human monoclonal antibody blocking SARS-CoV-2 infection. Nat Commun, 11(1), 2251. doi:10.1038/s41467-020-16256-y
Watanabe, Y., Allen, J. D., Wrapp, D., McLellan, J. S., & Crispin, M. (2020). Site-specific glycan analysis of the SARS-CoV-2 spike. Science. doi:10.1126/science.abb9983
Wrapp, D., De Vlieger, D., Corbett, K. S., Torres, G. M., Wang, N., Van Breedam, W., . . . McLellan, J. S. (2020). Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies. Cell, 181(5), 1004-1015 e1015. doi:10.1016/j.cell.2020.04.031
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C. L., Abiona, O., . . . McLellan, J. S. (2020). Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science, 367(6483), 1260-1263. doi:10.1126/science.abb2507
Yan, R., Zhang, Y., Li, Y., Xia, L., Guo, Y., & Zhou, Q. (2020). Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science, 367(6485), 1444-1448. doi:10.1126/science.abb2762
研究工具:
应用范围 |
研究工具 |
货号 |
优惠活动 |
蛋白检测 |
Strep-Tactin® HRP Conjugate |
2-1502-001 |
单次订购蛋白纯化填料/预装柱2支以上,即可获赠检测抗体一支(cat # 2-1509-002) |
Strep-Tactin®XT DY-488 conjugate |
2-1562-050 |
Strep-Tactin®XT DY-649 conjugate |
2-1568-050 |
StrepMAB-Classic, unconjugated |
2-1507-001 |
StrepMAB-Classic, HRP conjugate |
2-1509-001 |
细胞检测 |
Strep-Tactin® PE for MHC I Streptamers |
6-5000-001 |
Strep-Tactin® PE for Fab Streptamers |
6-5001-005 |
Strep-Tactin® APC for MHC I Streptamers |
6-5010-001 |
MHC I Streptamer® Custom Service |
定制服务 |
细胞分选 |
CD8 Fab-TACS® Isolation Kit, human |
6-3203-004 |
订购Introductory Kit即享折扣优惠 |
CD8 Fab-TACS® Isolation Kit, human |
6-3203-010 |
CD19 Fab-TACS® Isolation Kit, human |
6-3213-004 |
CD19 Fab-TACS® Isolation Kit, human |
6-3213-010 |
外泌体分离 |
CD9 Fab-TACS® Exosome Isolation Kit, human |
6-3219-004 |
新品折扣优惠!试用装免费申领! |
CD9 Fab-TACS® Exosome Isolation Kit, human |
6-3219-010 |
CD81 Fab-TACS® Exosome Isolation Kit, human |
6-3281-004 |
CD81 Fab-TACS® Exosome Isolation Kit, human |
6-3281-010 |
CD9/CD81 Fab-TACS® Exosome Isolation Starter Kit, human |
6-3295-004 |
CD9 Fab-TACS® Exosome Isolation Introductory Kit, human |
6-3296-002 |
CD81 Fab-TACS® Exosome Isolation Introductory Kit, human |
6-3297-002 |
蛋白纯化 |
Strep-Tactin® Sepharose® |
2-1201-010 |
Strep-Tactin®XT 试用装免费申领 |
Strep-Tactin® Superflow® |
2-1206-025 |
Strep-Tactin®XT Superflow® cartridge |
2-4021-001 |
Strep-Tactin®XT Superflow® high capacity cartridge |
2-4026-001 |
MagStrep “type3” beads |
2-4090-002 |
Protein A Agarose |
6-2010-005 |