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- Adipogen
- 瑞士
- BVT-0152-M001
- 2026年03月02日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
1年
- 英文名：
Tropodithietic acid [TDA]
- 库存：
大量
- 供应商：
欣博盛
- CAS号：
750590-18-2
- 规格：
5 mg/1 mg
| 规格： | 5 mg | 产品价格： | ￥4560.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1200.0 |
Description
Antibiotic. Isomeric to thiotropocin.
Antibacterial. Active against Gram-positive and Gram-negative bacteria.
Antifungal and anti-nematodical.
Shows antitumor activity.
Cytotoxic against selected mammalian neuronal cell lines.
Bacterial signal substance.
Acts as potent membrane antiporter for protons in exchange for cytoplasmic cations (e. g., K+). TDA collapses the cellular proton motive force (PMF) by affecting the transmembrane proton gradient but not the membrane potential.
Synonyms TDA
Product Type Chemical
Properties
Formula
C8H4O3S2
MW 212.3
CAS 750590-18-2
Source/Host Chemicals Isolated from Roseobacter gallaeciensis.
Purity Chemicals ≥90% (HPLC)
Appearance Orange solid.
Solubility Soluble in DMSO, methanol or ace-tone.
Identity Determined by 1H-NMR and UV.
Declaration Manufactured by BioViotica.
InChi Key BLFCMITWMARUSM-UHFFFAOYSA-N
Smiles OC(=O)C1=C2SSC2=CC=CC1=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Store solutions at -20°C in the dark.
Adipogen提供癌症、免疫、炎症、代谢疾病(糖尿病、肥胖)、干细胞和神经退行性疾病等领域生命科学研究试剂。重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，还拥有自己的化学实验室，致力于开发创新型小分子化合物。
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文献和实验- Thiotropocin, a new sulfur-containing 7-membered-ring antibiotic produced by a Pseudomonas sp.: K. Kintaka, et al.; J. Antibiot. 37, 1294 (1984)
- Thiotropocin biosynthesis. Shikimate origin of a sulfur-containing tropolone derivative: D.E. Cane, et al.; JACS 114, 8479 (1992)
- Investigation of secondary metabolites of North Sea bacteria: fermentation, isolation, structure elucidation and bioactivity: L. Liang; Dissertation Univ. Goettingen page 1-136 (2003) [TDA isolation, spectral data, cryst. Structure]
- Antibiotic production by a Roseobacter clade-affiliated species from the German Wadden Sea and its anta-gonistic effects on indigenous isolates: T. Brinkhoff, et al.; Appl. Environ. Microbiol. 70, 2560 (2004)
- Computational studies of the tropone natural products, thiotropocin, tropodithietic acid, and troposulfenin. Significance of thiocarbonyl-enol tautomerism: E.M. Greer, et al.; J. Org. Chem. 73, 280 (2008)
- Genetic dissection of tropodithietic acid biosynthesis by marine Roseobacters: H. Geng, et al.; Appl. Environ. Microbiol. 74, 1535 (2008)
- Expression of tropodithietic acid biosynthesis is controlled by a novel autoinducer: H. Geng & R. Belas; J. Bacteriol. 192, 4377 (2010)
- Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select: C. H. Porsby, et al.; Antimicrob. Agents Chemother. 55, 1332 (2011)
- A novel inducer of Roseobacter motility is also a disruptor of algal symbiosis: P. Sule & R. Belas; J. Bacteriol. 195, 637 (2013)
- Characterisation of non-autoinducing tropodithietic acid (TDA) production from marine sponge Pseudovibrio species: C. Harrington, et al.; Mar. Drugs 12, 5960 (2014)
- Biosynthesis of the antibiotic tropodithieticacid by the marine bacterium Phaeobacter inhibens: N.L. Brock, et al.; Chem. Comm. 50, 5487 (2014)
- Phaeobacter inhibens from the Roseobacter clade has an environmental niche as a surface colonizer in harbors: L. Gram, et al.; System. Appl. Microbiol. 38, 483 (2015)
- Cytotoxic effects of tropodithietic acid on mammalian clonal cell lines of neuronal and glial origin: H. Wichmann, et al.; Mar. Drugs 13, 7113 (2015)
- Influence of iron on production of the antibacterial compound tropodithietic acid and its noninhibitory analog in Phaeobacter inhibens: P. W. D`Alvise, et al.; Appl. Environ. Microbiol. 82, 502 (2016)
- Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ glutamyl cycle as a proton sink: M. Wilson, et al.; PNAS 113, 1630 (2016)
- Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens: P.G. Beyersmann, et al.; Sci. Rep. 7, 730 (2017)
- Diversity and antimicrobial activity of hydrobionts associated microorganisms from the sea of Japan with the occurrence of tropodithietic acid producing bacteria: L. A. Romane-nko, et al.; Microbiol. Res. J. Int. 20, MRJI.34949/1 (2017)
- Antimicrobial and antibiofilm molecules produced by marine bacteria: F. Desriac, et al.; Blue Biotechnol. J. 2, 789 (2018)
- Tropodithietic acid induces oxidative stress response, cell envelope biogenesis and iron uptake in Vibrio vulnificus: K.K. Dittmann, et al.; Environ. Microbiol. Rep. 11, 581 (2019)
- Bacterial tropone natural products and derivatives: overview of their biosynthesis, bioactivities, ecological role and biotechnological potential: Y. Duan, et al.; ChemBioChem 21, 1 (2020)
Potassium hydroxide (KOH) powder (purity, ≥85%; Sigma) Anhydrous acetonitrile (MeCN) Tris[2‐(2‐methoxyethoxy)ethyl]amine (TDA
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