anti-BAFF (mouse), mAb (blocki

anti-BAFF (mouse), mAb (blocking) (Sandy-2) (preservative free)产品货号AG-20B-0063PF，由Adipogen公司研发生产，欣博盛生物是Adipogen公司授权一级代理商，如需购买Adipogen公司产品，技术问题，请联系欣博盛生物。热销品常备现货~

BAFF is a master regulator of peripheral B cell survival and, together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).

Synonyms    BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B
Product Type    Monoclonal Antibody
Properties
Clone    Sandy-2
Isotype    Mouse IgG1κ
Source/Host    Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen    Recombinant mouse BAFF.
Label/Conjugates    Preservative Free
Application    
Functional Application: Inhibition of mouse BAFF binding to BAFF-R and TACI (BCMA not tested); blocks BAFF activity in mice. Injection of the anti-BAFF (mouse), mAb (Sandy-2) in mice creates a BAFF KO phenotype within 2 weeks, that can be maintained as long as necessary (> 6 months) by further injections of Sandy-2 every 2 weeks.
Immunoprecipitation: (1:200)

Crossreactivity    Mouse
Specificity    
Recognizes mouse BAFF.

Purity    ≥95% (SDS-PAGE)
Purity Detail    Protein G-affinity purified.
Endotoxin Content    <0.01EU/μg purified protein (LAL test).
Concentration    1mg/ml
Formulation    Liquid. In PBS.
Isotype Negative Control    
Mouse IgG1 Isotype Control (preservative free)

Other Product Data    
Note: BAFF and APRIL contribute to maintaining IgG, IgA, and IgM plasma cells in the bone marrow (BM), spleen, and intestine and rely mainly on three ligand/receptor pairs: APRIL-BCMA, BAFF-TACI, and APRIL-TACI. Together, these actors account for 90% of circulating antibodies. To efficiently target plasma cells, dual inhibition of BAFF (using blocking anti-BAFF (mouse), mAb (Sandy-2) (Prod. No. AG-20B-0063PF)) and APRIL (using blocking anti-APRIL (mouse), mAb (blocking) (Centotto-1) (Prod. No. AG-20B-0083PF) both developed at AdipoGen Life Sciences are required in a recently published study (see also Figure).

Shipping and Handling
Shipping    BLUE ICE
Short Term Storage    +4°C
Long Term Storage    +4°C
Handling Advice    Do not freeze.
Use/Stability    Stable for at least 1 year after receipt when stored at +4°C.

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