- ￥1700 - 4000
- GeneTex
- 美国
- GTX132416
- 2025年07月10日
- WB
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Carrier-protein conjugated synthetic peptide surrounding mutant K117N of human N-Ras. The exact sequence is proprietary.
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
12 months from the shipping date of the product.
- 抗原来源：
Human
- 目录编号：
GTX132416
- 级别：
Primary Antibodies
- 库存：
Available
- 供应商：
GeneTex
- 宿主：
Rabbit
- 应用范围：
WB
- 浓度：
1 mg/ml (Please refer to the vial label for the specific concentration.)
- 靶点：
RAS (K117N Mutant)
- 抗体英文名：
RAS (K117N Mutant) antibody
- 抗体名：
RAS (K117N Mutant) 抗体
- 规格：
100 μl/25 μl
| 规格： | 100 μl | 产品价格： | ￥4000.0 |
|---|---|---|---|
| 规格： | 25 μl | 产品价格： | ￥1700.0 |
Non-transfected (–) and transfected (+) 293T whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with RAS (K117N Mutant Specific) antibody (GTX132416) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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文献和实验Detection of K-ras and p53 Mutations by Mutant-Enriched PCR-RFLP
, since they fulfill many criteria that link their de novo appearance to the process of field cancerization (4 ). Oncogene mutations of the ras - and p53 -type are found in chronic smokers and patients with preneoplastic and neoplastic lesions
Ras 信号通路 很多生长因子如EGF、PDGF、FGF等激活受体酪氨酸激酶后，通过中介分子可活化由原癌基因FaS编码的Ras蛋白 ，后者能进一步催化其底物蛋白的酪氨酸磷酸化反应，并引发蛋白磷酸化的级联反应，最终导致细胞的增殖效应。由于Ras蛋白为多种生长因子信号转导过程所共有，故把此信号转导途径称为Ras通路。 Ras蛋白是癌基因las的编码产物，人类有3种ras基因，即H―FaS、K―las和N―Fas，分布于不同染色体上，能编码蛋白质P21。所有的Ras―P21均有结合鸟
Detection of ras Gene Mutations Using Oligonucleotide Ligation Technology
The human ras genes (H-, K-, and N-rus ) are members of a superfamily of low-mol-wt GTP-binding proteins that function as G proteins in signal transduction pathways controlling cell proliferation and differentiation (1 ,2 ). Ras genes
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