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产品名称:WIN 18,446
别名:NSC 59354
产品描述:WIN 18,446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2, (IC50 = 300 nM), a testes-specific isoform of the enzyme involved in vitamin A metabolism.{23122} In this way, WIN 18,446 suppresses the expression of several genes that are regulated by retinoic acid and are necessary for spermatogenesis.{23123,23122} As a result, WIN 18,446 may cause infertility in males.{23123,23122}
保存温度:-20
运输温度:-20
预期分子量:366.1
产品形式:A crystalline solid
有效期:730
产地:美国
纯度:≥98%
CAS号:1477-57-2
分子式:C12H20Cl4N2O2