运输和保存方法冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。 注意事项1. 为了您的安全和健康,请穿实验服并戴一次性手套操作。 2.粉末溶解前请先短暂离心,以保证产品全在管底。 3. 请勿吸入、吞咽或者直接接触皮肤和眼睛。 4.本产品仅用于科研用途,禁止用于人身上。 使用浓度【具体使用浓度请参考相关文献,并根据自身实验条件(如实验目的,细胞种类,培养特性等)进行摸索和优化。】 使用方法(数据来自于公开发表的文献,仅供参考)(一)细胞实验(体外实验) 在L. monocytogenes EGDe感染的骨髓源小鼠巨噬细胞模型中,通过时间杀伤曲线和细胞内生长抑制实验比较莫西沙星和阿莫西林的体外活性,结构发现莫西沙星作用更快,在前3小时就开始发挥作用,并在24小时内实现完全灭菌。莫西沙星似乎对巨噬细胞溶解有保护作用,因为许多细胞在孵育24小时后仍能存活。[3] (二)动物实验(体内实验) 在感染Stenotrophomonas maltophilia大鼠模型中,静脉注射Moxifloxacin (12mg/kg)延长了大鼠的存活率,脾脏和肺部的细菌过度生长明显减少。[4] 参考文献 1.Culley, C.M., et al., Moxifloxacin: clinical efficacy and safety. Am J Health Syst Pharm. 2001 Mar 1;58(5):379-88. 2.Grayo S, et al. Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. Antimicrob Agents Chemother. 2008 May;52(5):1697-702. 3.Balfour JA, et al. Moxifloxacin: a review of its clinical potential in the management of community-acquired respiratory tract infections. Drugs. 2000 Jan;59(1):115-39. 4.Ioannidis O, et al. Effect of moxifloxacin on survival, lipid peroxidation and inflammation in immunosuppressed rats with soft tissue infection caused by Stenotrophomonas maltophilia. Microbiol Immunol. 2014 Feb;58(2):96-102.
1.Culley, C.M., et al., Moxifloxacin: clinical efficacy and safety. Am J Health Syst Pharm. 2001 Mar 1;58(5):379-88. 2.Grayo S, et al. Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. Antimicrob Agents Chemother. 2008 May;52(5):1697-702. 3.Balfour JA, et al. Moxifloxacin: a review of its clinical potential in the management of community-acquired respiratory tract infections. Drugs. 2000 Jan;59(1):115-39. 4.Ioannidis O, et al. Effect of moxifloxacin on survival, lipid peroxidation and inflammation in immunosuppressed rats with soft tissue infection caused by Stenotrophomonas maltophilia. Microbiol Immunol. 2014 Feb;58(2):96-102.