生物学描述Selective STAT3 signaling inhibitor (IC50 = 0.25-0.5 μM, IL-6-mediated JAK/STAT signaling). Selectively blocks binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. Induces apoptosis. Shows antitumor and anti-inflammatory effects in vivo.
存放说明Store at -20°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
溶解度概述Soluble in ethanol and in DMSO
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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