A-740003抑制剂、激动剂(CAS号861393-28-4)A-740003是P2X7受体选择性抑制剂,对鼠和人P2X7受体的IC50分别为18和40 nM。 A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively).
IC50 value: 18 nM/40 nM(P2X7 Rat/Human)
Target: P2X7 receptor
A-740003 displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. A-740003 reduces nociception in animal models of persistent neuropathic and inflammatory pain.