DB07268抑制剂、激动剂(CAS号929007-72-7)DB07268是JNK1抑制剂,IC50为9 nM。 DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.
IC50 Value: 9 nM (Human JNK1) [1]
Target: JNK1
This compound has some degree of selectivity over quite a few kinases with the exceptions of CHK1, CK2, and PLK. Although compound 2b(DB-07268) shows submicromolar potency against these three kinases, it still appears to exhibit at least 70- to 90-fold
greater potency against JNK1 than CHK1, CK2, and PLK.