Phenoxybenzamine hydrochloride抑制剂、激动剂(CAS号63-92-3)Phenoxybenzamine hydrochloride (盐酸酚苄明) 是非特异性的不可逆的α肾上腺素受体长效拮抗剂。 Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with long duration of action.
Target: Alpha Adrenergic Receptor
Phenoxybenzamine (PB), a classical alpha-adrenergic antagonist, binds irreversibly to the alpha-adrenergic receptors (ARs). The IC50 (100 nM) derived from the blockade of [3H]yohimbine binding by phenoxybenzamine was significantly less than the IC50 (550 nM) for the corresponding reversal by phenoxybenzamine of the effects of norepinephrine on cyclic AMP accumulation. Further studies demonstrated a rightward shift in the dose-response curves for the inhibition by norepinephrine of cyclic AMP accumulation following pretreatment with increasing phenoxybenzamine concentration [1].