Streptomycin sulfate抑制剂、激动剂(CAS号3810-74-0)Streptomycin sulfate (硫酸链霉素) 是氨基糖苷类抗生素,由土壤中灰色链霉菌生成。 Streptomycin is an aminoglycoside antibiotic produced by the soil actinomycete Streptomyces griseus.
Target: Antibacterial
Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor. It binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit. This leads to codon misreading, eventual inhibition of protein synthesis and ultimately death of microbial cells through mechanisms that are still not understood. Speculation on this mechanism indicates that the binding of the molecule to the 30S subunit interferes with 50S subunit association with the mRNA strand. This results in an unstable ribosomal-mRNA complex, leading to a frameshift mutation and defective protein synthesis; leading to cell death. Humans have structurally different ribosomes from bacteria, thereby allowing the selectivity of this antibiotic for bacteria. At low concentrations, however, Streptomycin only inhibits growth of the bacteria by inducing prokaryotic ribosomes to misread mRNA. Streptomycin is an antibiotic that inhibits both Gram-positive and Gram-negative bacteria, and is therefore a useful broad-spectrum antibiotic [1, 2].