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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
20(S)-Propanaxadiol; S-ginsenoside Rg3
货期:1-2天
MedChemExpress LLC
14197-60-5
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
规格: | 10 mM * 1 mL | 产品价格: | ¥563.0 |
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规格: | 1 mg | 产品价格: | ¥160.0 |
规格: | 5 mg | 产品价格: | ¥320.0 |
规格: | 10 mg | 产品价格: | ¥512.0 |
规格: | 50 mg | 产品价格: | ¥1097.0 |
规格: | 100 mg | 产品价格: | ¥1953.0 |
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CAS No. : 14197-60-5
MCE 国际站:20(S)-Ginsenoside Rg3
产品活性:20(S)-Ginsenoside Rg3 是人参的主要成分。20(S)-Ginsenoside Rg3 抑制 Na+ 和 hKv1.4 通道,IC50 分别为 32.2±4.5 和 32.6±2.2 μM。20(S)-Ginsenoside Rg3 还抑制 Aβ,NF-κB 活性和 COX-2 表达。
研究领域:Membrane Transporter/Ion Channel | NF-κB | Immunology/Inflammation | Neuronal Signaling | Metabolic Enzyme/Protease
作用靶点:Sodium Channel | Potassium Channel | NF-κB | COX | Amyloid-β | Endogenous Metabolite
In Vitro: Ginsenoside Rg3 plays an important role in its effect on the Na+ channel. Treatment with Ginsenoside Rg3 reversibly inhibits the inward Na+ peak current (INa) with an IC50 of 32.2±4.5 μM, and the inhibition is voltage-dependent. Ginsenoside Rg3 at 100 μM inhibits the hKv1.4 channel currents by an average of 65%.The Ginsenoside Rg3 effect is concentration-dependent and reversible. The IC50 value and Hill coefficient are 32.6±2.2 μM and 1.59±0.13, respectively. Ginsenoside Rg3 shows the significant inhibition of NF-κB activity thereby reduced COX-2 expression. To examine the cytotoxicity of Ginsenoside Rg3 on IL-1β-induced inflamed A549 cells, the cells are firstly treated with IL-1β (10 ng/mL) for 4 h and treated with 100 to 900 ng/mL concentration of Ginsenoside Rg3 for 12 h. Cell viability is analyzed using an MTT assay. There is no observed cytotoxicity of Ginsenoside Rg3 in IL-1β-induced inflamed A549 cells compared to only PBS-treated cells (Con).To obtain the anti-inflammatory effects of Ginsenoside Rg3 on inflammation induced human lung epithelial cells, A549 cells inflammation is induced by IL-1β (10 ng/mL) and then treated by 5 μM of Dexamethasone (Dex) or 900 nM of Rg3. The NF-κB activation is analyzed by a western blot analysis to evaluate the effect of Ginsenoside Rg3 treatment on A549 cells. Phospho-NF-κB p65/total NF-κB p65 densitometry in the cells treated with Rg3 shows the significant decrease compared to IL-1β-induced inflamed A549 cells. The meaning of reducing the ratio of p-p65/p65 by Rg3 treatment is associated with NF-κB activation. Ginsenoside Rg3 also downregulates the expression of COX-2 effectively.
In Vivo: Ginsenoside Rg3 ((20S)-Rg3) is an Aβ-lowering Natural Compound. APP/PS1 mice are treated with Ginsenoside Rg3 once a day for 4 weeks by intraperitoneal injection (10 mg/kg/day). Aβ ELISA analysis of brain tissues reveal that Ginsenoside Rg3 treatment results in a significant reduction of Aβ40 and Aβ42 in the brain.
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