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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Mevinolin
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/10 mg/25 mg/50 mg/100 mg/200 mg/500 mg/1 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥266.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥222.0 |
| 规格： | 25 mg | 产品价格： | ￥399.0 |
| 规格： | 50 mg | 产品价格： | ￥599.0 |
| 规格： | 100 mg | 产品价格： | ￥871.0 |
| 规格： | 200 mg | 产品价格： | ￥1200.0 |
| 规格： | 500 mg | 产品价格： | ￥2100.0 |
| 规格： | 1 g | 产品价格： | ￥3100.0 |
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Lovastatin
CAS No. : 75330-75-5
MCE 国际站：Lovastatin
产品活性：Lovastatin是一种用于降低胆固醇的细胞渗透性的 HMG-CoA还原酶抑制剂。
研究领域：Metabolic Enzyme/Protease | Autophagy | Apoptosis
作用靶点：HMG-CoA Reductase (HMGCR) | Autophagy | Ferroptosis
In Vitro: Lovastatin (10 μM; 72 hours) efficiently reduces viability of HepG2 cells.
?Lovastatin (10 μM; 48 hours) induces apoptosis in HepG2 cells.
In Vivo: Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol.
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文献和实验降血脂药他汀类无论是之前成熟的发酵品种，还是当下发展迅速的全合成产品，一直是处于不断革新和改进的状态，特别是新的酶法工艺的发展，引领着市场的走势。 从整体环境看，我国的环保、安全成本将继续逐步加大，人力成本持续上涨，这些必然的趋势所带来的，是所谓的“中国制造”优势的部分散失。 目前全球包括美国在内，都在流行“制造业回归”，虽然和化学原料这种环境污染压力较大的品种情况会不一样，但印度开始大量输出洛伐他汀的情况，无疑是这样一个大经济环境下的一个缩影。而技术革新和进步，才是目前左右他汀
- 0.44 5 锂盐 lithium 100 95 0 0.35 0.79 22 洛伐他汀 lovastatin 5 95 5～21 -
霉素lincomycin 100 20 72 - 0.44 5 锂盐lithium 100 95 0 0.35 0.79 22 洛伐他汀lovastatin 5 95 5～21 -
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