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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- CAS号：
1617-90-9
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10 mM * 1 mL/100 mg/500 mg/1 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥220.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥200.0 |
| 规格： | 500 mg | 产品价格： | ￥400.0 |
| 规格： | 1 g | 产品价格： | ￥600.0 |
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Vincamine
CAS No. : 1617-90-9
MCE 国际站：Vincamine
产品活性：Vincamine 是从马达加斯加长春花中提取的一种单萜类吲哚生物碱。Vincamine 可以作为一种外周血管扩张剂 (Vasodilator)，对脑微血管循环有选择性的血管调节作用。Vincamine 是一种 GPR40 激动剂，通过改善 β 细胞功能障碍和促进葡萄糖刺激型胰岛素分泌 (GSIS) 发挥 β 细胞保护作用。Vincamine 可改善体内葡萄糖稳态，对 2 型糖尿病 (T2DM) 的研究具有潜力。
研究领域：GPCR/G Protein
In Vitro: Vincamine (20, 40 and 80 μM; 24 hours) exerts a significant, concentration-dependent protective effect in LPS-treated human corneal epithelial cells (HCECs) cells.
Vincamine (20, 40 and 80 μM; 24 hours) significantly reduces ROS level in a dose-dependent manner in LPS-treated human corneal epithelial cells (HCECs)cells. Additionally, after Vincamine administration, the levels of MDA is also significantly reduced while the levels of T-AOC, and SOD are increased in a dose-dependent manner.
Vincamine (20, 40 and 80 μM; 24 hours) rescues TrxR activity in a dose-dependent manner in HCECs. However, the intracellular activities of Trx, GR and GPx are neither inhibited nor activated by both LPS and Vincaminer.
Vincamine could activate GPR40 (EC50=6.28 µM) with DHA (GPR40 ligand) as a positive control (EC50=3.85 µM) in hGPR40-CHO cells.
In Vivo: Vincamine (intraperitoneal injection; 15 and 30 mg/kg/day; 6 weeks) improves glucose tolerance in type 2 diabetic model mice. It effectively lowers the levels of fasting blood glucose and glycated hemoglobin. At the same time, it ameliorates oral glucose tolerance and elevated glucose-induced plasma insulin concentration without influence on basal insulin secretion in vivo.<.br>
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文献和实验剂的密封塑料袋（相对湿度为23%）中放置4小时。• 37°C 下，相对湿度为26%的烘箱中烘干2小时。作为负对照，在室温下，将一些板放入不含干燥剂的潮湿的铝箔袋中，密封保存90分钟。这些经过干燥的平板接着被密封图3 抗兔单克隆抗体活性保留的百分比；这些抗体均经过Stabilguard 或者Superblock 处理，并分别采用4种不同方式进行干燥（包括一个未干燥处理的负对照），最后在室温下保存6到12个月。在放有干燥剂的铝箔袋中并在室温下保存，以便对长时间的稳定性进行评估。抗体活性的回收率通过酶联
the generation of normalized, full?length?enriched cDNA libraries, and enabling efficient RNA analyses. Curr. Protoc. Mol. Biol. 90:5.12.1?5.12.27. © 2010 by John Wiley & Sons, Inc. Keywords: cDNA normalization; duplex?specific nuclease (DSN
Overview of Animal Models of Obesity
. Becskei, C., Lutz, T.A., and Riediger, T. 2009. Blunted fasting‐induced hypothalamic activation and refeeding hyperphagia in late‐onset obesity. Neuroendocrinology 90:371‐382
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