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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Dibutyryl cAMP calcium salt; DBcAMP calcium salt
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥715.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥650.0 |
| 规格： | 100 mg | 产品价格： | ￥800.0 |
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Bucladesine calcium
CAS No. : 938448-87-4
MCE 国际站：Bucladesine calcium
产品活性：Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) 是可渗透细胞的 cAMP 类似物，可通过增加细胞内 cAMP 水平，选择性激活 cAMP 依赖性蛋白激酶(PKA)。Bucladesine calcium salt 也有磷酸二酯酶 (PDE) 抑制剂的作用。
研究领域：Stem Cell/Wnt | Metabolic Enzyme/Protease | Apoptosis
作用靶点：PKA | Phosphodiesterase (PDE) | Apoptosis
In Vivo: Bucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats.
?Bucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine.
?Bucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Bucladesine is absorbed rapidly but slower than in the full-thickness abrasion rat model in the case of stripped skin.
?Bucladesine (single or multiple administration of an emulsion containing 1.5%) is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice.
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文献和实验The Effects of Calcium-Free Seawater on the Development of Sea Urchin Embryos
Objective The purpose of this experiment is to determine the effects of calcium-free seawater on the development of sea urchin embryos. Embryos were placed in calcium-free sea after fertilization and at the initiation of gastrulation
Measurement of Intracellular Calcium with Fluorescent Calcium Indicators
Changes in cytosolic free calcium ion concentration ([Ca2+ ]i ) accompany many cellular transitions and stimulation of cell surface receptors. Both release of Ca2+ from internal stores and Ca2+ entry through plasma membrane ion channels
The involvement of calcium (Ca) in living organisms has long been recognized, particularly its presence in invertebrate shells and vertebrate bones. It was not, however, before the studies of S. Ringer (1882), who showed that its presence
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