Lercanidipine盐酸乐卡地平,132866-11-

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Lercanidipine hydrochloride

CAS No. : 132866-11-6

MCE 国际站：Lercanidipine hydrochloride

产品活性：Lercanidipine 是第三代、亲脂性、可穿透血脑屏障、血管选择性、具有口服活性的二氢吡啶钙通道阻断剂，pIC₅₀ 为 7.74(由 微摩尔浓度 转换而来)。Lercanidipine 具有持久的降压作用以及肾脏和神经保护作用，还具有抗氧化、抗炎和抗凋亡的特性。Lercanidipine 可用于心血管和神经学研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Apoptosis  |  NF-κB  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  MAPK/ERK Pathway

作用靶点：Calcium Channel  |  Apoptosis  |  Reactive Oxygen Species  |  p38 MAPK  |  NF-κB

In Vitro: Lercanidipine (1, 10 μM, 24 h) exerts suppression of NO, ROS and TNF-a through down-regulation of iNOS, MMP-2/MMP-9, and HMGB1, as well as inhibition of MAPKs, Akt/IkB-a and NF-kB pathways in LPS/IFN-γ-induced VSMCs.

In Vivo: Lercanidipine (1, 0.5 and 0.25 mg/kg, i.p., acute administration) significantly reduces neurological deficit score, motor deficits and cerebral infarction volume in the MCAo model rats.
Lercanidipine (1.92-0.12 mg/kg, p.o., acute administration) lowers blood pressure effectively and dose-dependently in spontaneous hypertensive rats.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Antiviral Compound Library  |  Drug Repurposing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Neuroprotective Compound Library  |  Calcium Channel Blocker Library  |  Human Metabolite Library  |  Off-patent Drug Library  |  Antihypertensive Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Ion Channel Compound Library  |  MG-132  |  Phorbol 12-myristate 13-acetate  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  LY294002  |  Tamoxifen  |  Paclitaxel  |  Y-27632  |  Acetylcysteine  |  Angiotensin II human  |  2-Deoxy-D-glucose  |  Staurosporine  |  H2DCFDA  |  SB-431542  |  Actinomycin D  |  Deferoxamine mesylate  |  Bortezomib  |  5-Fluorouracil  |  Trametinib  |  Sorafenib  |  Oxaliplatin  |  Gemcitabine  |  Temozolomide  |  Adezmapimod  |  Rotenone  |  Mdivi-1  |  Elesclomol  |  Ruxolitinib  |  Decitabine  |  SP600125

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds