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- MedChemExpress(MCE)
- 美国
- HY-B0526
- 2026年09月15日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
R-802
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
42835-25-6
- 规格：
10 mM * 1 mL/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥610.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥550.0 |
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Flumequine
CAS No. : 42835-25-6
MCE 国际站：Flumequine
产品活性：Flumequine (R-802) 是一种喹诺酮类抗生素，为拓扑异构酶 II (Topoisomerase II) 抑制剂，IC50 值为 15 μM (3.92 μg/mL)。
研究领域：Anti-infection | Cell Cycle/DNA Damage
作用靶点：Bacterial | Topoisomerase | Antibiotic
In Vitro: Flumequine (R-802) is a topoisomerase II inhibitor, with an IC50 of 3.92 μg/mL, and less potently inhibits Gyrase, with an IC50 of 1764 μg/mL. Flumequine (0-625 μg/mL) increases migration of nuclear DNA from CHL cells. Flumequine (R-802) inhibits Spanish field isolates of B. hyodysenteriae with MIC50 and MIC90 of 50 and 100 μg/mL, and MBC50 and MBC90 of 50, 200 μg/mL, respectively. Flumequine (R-802) suppresses A. salmonicida isolates with MIC ranging from 0.06 to 32 μg/mL.
In Vivo: Flumequine (R-802) (0-500 mg/kg, p.o.) causes dose-related DNA damage in the stomach, colon, and urinary bladder of mice, 1 and 3 h but not 24 h after its administration.
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