Pardoprunox盐酸帕多芦诺,269718-83-4

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Pardoprunox hydrochloride

CAS No. : 269718-83-4

MCE 国际站：Pardoprunox hydrochloride

产品活性：Pardoprunox (SLV-308) hydrochloride 是多巴胺受体 D2、D3 部分激动剂和 5-HT1A 激动剂，pEC₅₀ 分别为 8, 9.2, 6.3。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor  |  Adrenergic Receptor  |  Dopamine Receptor

In Vitro: Pardoprunox (SLV-308) hydrochloride acts as a potent but partial D2 receptor agonist (pEC₅₀= 8.0 and pA₂=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC₅₀=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA₂=9.0). Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC₅₀=6.3).

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Endocrinology Compound Library  |  Anti-COVID-19 Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Alzheimer's Disease Compound Library  |  Anti-Parkinson's Disease Compound Library  |  Anti-Obesity Compound Library  |  Rare Diseases Drug Library  |  Antidepressant Compound Library  |  5-HT Receptor Compound Library  |  Coagulation and Anti-coagulation Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Activators Library  |  Dopamine Receptor Compound Library  |  Isoprenaline hydrochloride  |  Clozapine N-oxide  |  MPTP hydrochloride  |  Norepinephrine  |  Zenidolol hydrochloride  |  Propranolol hydrochloride  |  Phenylephrine  |  Oxidopamine hydrobromide  |  Chlorpromazine hydrochloride  |  CL 316243  |  Serotonin hydrochloride  |  L-DOPA  |  Harmine  |  Puerarin  |  Dopamine hydrochloride  |  SCH-23390 hydrochloride  |  Metoprolol  |  Carvedilol  |  Haloperidol  |  L-Epinephrine  |  Atenolol  |  PNU-282987  |  SKF 38393 hydrochloride  |  Pimozide  |  Prazosin hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds