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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
50-35-1
- 规格：
10 mM * 1 mL/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥616.0 |
|---|---|---|---|
| 规格： | 200 mg | 产品价格： | ￥560.0 |
| 规格： | 500 mg | 产品价格： | ￥1000.0 |
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Thalidomide
CAS No. : 50-35-1
MCE 国际站：Thalidomide
产品活性：Thalidomide 能够抑制 cereblon (cullin-4 E3 泛素连接酶复合物 CUL4-RBX1-DDB1 的一部分)，Kd 值约为 250 nM，具有免疫调节、抗炎、抗肿瘤作用。Thalidomide 可以作为分子胶来增强底物。
研究领域：PROTAC | Autophagy | Apoptosis | Anti-infection
作用靶点：Ligands for E3 Ligase | Molecular Glues | Autophagy | Apoptosis | Bacterial
In Vitro: Thalidomide has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties, and targets cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ～250 nM.
Thalidomide (50 μg/mL) potentiates the anti-tumor activity of Icotinib against the proliferation of both PC9 and A549 cells, and this effect is correlated with apoptosis and cell migration. In addition, Thalidomide and Icotinib inhibits the EGFR and VEGF-R2 pathways in PC9 cells.
In Vivo: Thalidomide (100 mg/kg, p.o.) inhibits the collagen deposition, down-regulates the mRNA expression level of α-SMA and collagen I, and significantly reduces the pro-inflammatory cytokines in RILF mice. Thalidomide alleviates RILF via suppression of ROS and down-regulation of TGF-β/Smad pathway dependent on Nrf2 status.
Thalidomide (200 mg/kg, p.o.) combined with Icotinib shows synergistic anti-tumor effects in nude mice bearing PC9 cells, suppressing tumor growth and promoting tumor death.
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文献和实验突变表型相似，但本质不同，用生化的方法是可以加以区分的。 在人类中也有很多表型模拟的例子，白内障、耳聋、心脏缺陷等有的是遗传的，也有的是由于患者的母亲在怀孕后2周内感染了麻疹病毒而引起。人类的其他一些性状也有表型模拟，如短肢畸型（phcomelia），这种畸型有的是受显性等位基因控制的，这个基因抑制了四肢长骨的发育。在1959~1961年之间，发现孕妇在妊娠35~50天若服用镇静剂反应停（thalidomide）也会使孩子产生同样的表型，现在这种药物早已被淘汰了。
、中毒性精神病及过敏反应。剂量过大还可引起肝损害及剥脱性皮炎。治疗早期或增量过快，患者可发生麻风症状加剧的反应（麻风反应），一般认为是机体对菌体裂解产生的磷脂类颗粒的过敏反应，多认为是预后良好的现象。麻风反应可用沙利度胺（thalidomide，反应停）防治。其他处理方法是减量停药或暂改用另一些抗麻风药，并用肾上腺皮质激素进行治疗。 二、其他药物 1. 利福平 对麻风杆菌包括对氨苯砜耐药菌株有快速杀菌作用，用药数日至数周，菌体即碎裂呈粒变现象。临床应用600或1200mg
3.73 3.61 3.51 3.44 3.37 3.28 3.18 3.07 2.96 2.85 2.72 12 13 4.96 4.35 4.00 3.77 3.60 3.48 3.39 3.31 3.25 3.15 3.05 2.95 2.84 2.72 2.59 13 14 4.86 4.24 3.89 3.66 3.50 3.38 3.28 3.21 3.15 3.05 2.95 2.84 2.73 2.61 2.49 14 15 4.76 4.15 3.80
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