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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
NSC 667219
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
599-79-1
- 规格：
10 mM * 1 mL/500 mg/1 g/5 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥400.0 |
| 规格： | 1 g | 产品价格： | ￥500.0 |
| 规格： | 5 g | 产品价格： | ￥800.0 |
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Sulfasalazine
CAS No. : 599-79-1
MCE 国际站：Sulfasalazine
产品活性：Sulfasalazine (NSC 667219) 常用于类风湿关节炎和溃疡性结肠炎的相关研究。Sulfasalazine 可抑制 NF-κB 的活性。Sulfasalazine 是 type 1 的铁死亡 (ferroptosis) 诱导剂。
研究领域：NF-κB | Autophagy | Apoptosis | Anti-infection
作用靶点：NF-κB | Autophagy | Apoptosis | Ferroptosis | Bacterial | Antibiotic
In Vitro: Treatment of SW620 colon cells with sulfasalazine inhibits TNFα-, LPS-, or phorbol ester-induced NFκB activation. NFκB-dependent transcription is inhibited by sulfasalazine at micro- to millimolar concentrations. TNFα-induced nuclear translocation of NFκB is prevented by sulfasalazine through inhibition of IκBα degradation. Pre-incubation with 5 mM of sulfasalazine alone significantly increases basal mRNA expression of all pro-inflammatory cytokines with levels of IL-6 mRNA increased by 80-fold compared with vehicle control. Once digested, sulfasalazine is cleaved into sulfapyridine and 5-aminosalicylic acid by colonic bacteria, and the latter, too, is reported to suppress NF-kappaB activity.
In Vivo: At low doses (0.25 mM), SAS is able to suppress glioma growth by over 60% compared to untreated controls.
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文献和实验, Tanacetum parthenium PPM-18 Sulfasalazine TIRAP Inhibitor Peptide, Cell-Permeable TIRAP Inhibitor Peptide, Control, Cell-Permeable Withaferin A, Withania somnifera LWP1981 我做细胞抑制的时候，用过好几次SN50，觉得SN50对NFKB转录因子的核转移抑制效果不错
磺吡啶（sulfasalazine,salicylazosulfapyridine）口服吸收较少，对结缔组织有特殊的亲和力并从肠壁结缔组织中释放出磺胺吡啶而起抗菌、抗炎和免疫抑制作用。适于治疗非特异性结肠炎，长期服用可防止发作。由于疗程长，易发生恶心，呕吐皮疹及药热等反应。 3.外用磺胺药 磺胺嘧啶银（sulfadiazine silver）能发挥SD及硝酸银两者的抗菌作用，抗菌谱广，对绿脓杆菌抑制作用强大，尚有收敛作用，能促进创面的愈合，适用于二度或三度烧伤。 磺胺米隆（sulfamylon,SML
磺吡啶（sulfasalazine,salicylazosulfapyridine）口服吸收较少，对结缔组织有特殊的亲和力并从肠壁结缔组织中释放出磺胺吡啶而起抗菌、抗炎和免疫抑制作用。适于治疗非特异性结肠炎，长期服用可防止发作。由于疗程长，易发生恶心，呕吐皮疹及药热等反应。 3.外用磺胺药 磺胺嘧啶银（sulfadiazine silver）能发挥SD及硝酸银两者的抗菌作用，抗菌谱广，对绿脓杆菌抑制作用强大，尚有收敛作用，能促进创面的愈合，适用于二度或三度烧伤。 磺胺米隆（sulfamylon,SML
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