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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
AT13387
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
912999-49-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥973.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥490.0 |
| 规格： | 5 mg | 产品价格： | ￥1080.0 |
| 规格： | 10 mg | 产品价格： | ￥1674.0 |
| 规格： | 25 mg | 产品价格： | ￥2850.0 |
| 规格： | 50 mg | 产品价格： | ￥4200.0 |
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Onalespib
CAS No. : 912999-49-6
MCE 国际站：Onalespib
产品活性：Onalespib (AT13387) 是一种长效的二代 Hsp90 抑制剂，Kd 值为 0.71 nM。
研究领域：Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点：HSP
In Vitro: Onalespib (Compound 35) is a potent inhibitor of Hsp90, with Kd of 0.71 nM. Onalespib shows potent antiproliferative activity in HCT116 cells, with an IC50 of 31 nM. Onalespib also strongly inhibits the proliferation of a panel of human tumor cell lines, showing IC50 of < 100 nM. Onalespib exhibits cytotoxic activity against many of the PPTP cell lines, with median IC50 of 41 nM.
In Vivo: Onalespib (60 mg/kg, ip 3 days on and 3 days off for four cycles) shows antitumor activity in nude BALB/c mice bearing early stage HCT116 human colon carcinoma xenografts. Onalespib (40 or 60 mg/kg, i.p.) induces significant differences in EFS distribution compared to controls in 17% evaluable solid tumor xenografts, but in none of the ALL xenografts.
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