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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1357389-11-7
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 50 mg | 产品价格： | ￥4200.0 |
| 规格： | 100 mg | 产品价格： | ￥6120.0 |
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RGFP966
CAS No. : 1357389-11-7
MCE 国际站：RGFP966
产品活性：RGFP966 是高选择性的 HDAC3 抑制剂，IC50 为 80 nM，在 15 μM 时对其他 HDAC 无抑制作用。RGFP966 能够透过血脑屏障 (BBB)。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：HDAC
In Vitro: RGFP966 potently and selectively inhibits HDAC 3 with IC50 of 0.21 μM in RAW 264.7 macrophages, while HDACs 1 (IC50=5.6 μM), 2 (9.7 μM) and 8 (>100 μM), indicating a good level of selectivity for HDAC 3. The mRNA levels of HDACs 1, 2 and 3 are not significantly affected by RGFP966 in RAW 264.7 macrophages, whereas the HDAC 1 and HDAC 2 protein levels are slightly, though significantly, reduced upon RGFP966 treatment. Moreover, RGFP966 significantly reduced the transcriptional activity of NF-κB p65, whereas NF-κB p65 acetylation and localization remain unaltered.
In Vivo: RGFP966 (10 and 25 mg/kg) treatment significantly improves body weight, rotarod performance and several measures of motor function in the open field locomoter test. RGFP966 at a 10 mg/kg dose penetrates the blood-brain barrier into rat auditory cortex with typical pharmacokinetics, which together establish feasibility for the modulation of A1 plasticity due to action in the auditory cortex.
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层析介质的实验使用实例，方便广大实验工作者。 下面是PALL“Q hyperCel”和“S hyperCel”用于“rGFP重组绿色荧光蛋白”和mAb抗体纯化的运用。便于大家参考。 1、“Q hyperCel”用于E.Coli裂解液rGFP的预纯化 2、“S hyperCel”用于纯化mAb抗体第二步环节
cDNA sequence: >unknown Genomic sequence: >unknown Blat alignment: Length of cDNA: 5799 Start in cDNA: 0 End in cDNA: 5799 Mismatches: 0 Gaps in genomic Seq: 0 (introns included) Gaps in cDNA: 0 Exon1_1: 966 bp,Product size 1081 Exon
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