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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
165800-06-6
- 规格：
50 mg/100 mg
| 规格： | 50 mg | 产品价格： | ￥800.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥1548.0 |
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Zoledronic acid monohydrate
CAS No. : 165800-06-6
MCE 国际站：Zoledronic acid monohydrate
产品活性：Zoledronic Acid monohydrate (Zoledronate monohydrate) 是第三代含氮二磷酸盐，具有高效的抗骨质再吸收活性。Zoledronic Acid monohydrate 能抑制破骨细胞的分化和凋亡。Zoledronic Acid monohydrate 也有抗癌作用。
研究领域：Apoptosis | Autophagy | Anti-infection
作用靶点：Apoptosis | Autophagy | Bacterial
In Vitro: Zoledronic Acid monohydrate (0.1-1 µM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells.
Zoledronic Acid monohydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells.
Zoledronic Acid monohydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells.
Zoledronic Acid monohydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.
Zoledronic Acid monohydrate (10-100 µM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells.
Zoledronic Acid monohydrate (10-100 µM; 1-7 days) induces apoptosis in MC3T3-E1 cells.
Zoledronic Acid monohydrate (10-100 µM; 4 days) inhibits cell viability due to the induction of apoptosis.
Zoledronic Acid monohydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 µM.
In Vivo: Zoledronic Acid monohydrate (0.05 mg/kg; i.p.; weekly; for 3 weeks) increases bone mineral density and content.
Zoledronic Acid monohydrate (0.5-1 mg/kg; i.p.; weekly; for 3 weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties.
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文献和实验Bicinchoninic Acid (BCA) Protein Assay (Smith)
Considerations for use The bicinchoninic acid (BCA)assay is available in kit form from Pierce (Rockford,Ill.).This procedure is very applicable to microtiter plate methods.The BCA is used for the same reasons the Lowry is used.Stoscheck (1990
A. Reagents 1. DMEM:10% FBS 2. DMEM:10% FBS:1% HEPES (DFH) 3. 10X Substrate Buffer, pH 6.0 36.6 g Citric Acid, monohydrate 113.5 g Potassium dibasic phosphate Dissolve in 900 ml di-H2O. Check pH and adjust to 6.0 if necessary. Qs
Peptide Inhibition ELISA Protocol
A. Reagents PBS PBS:0.1% BSA:0.05% Tween 20 (PBT) PBS:2% BSA 10X Substrate Buffer, pH 6.036.6 g Citric Acid, monohydrate113.5 g Potassium dibasic phosphateDissolve in 900 ml
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