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- 2025年12月05日
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- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Pergolide methanesulfonate; LY127809
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
66104-23-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥542.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥273.0 |
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥800.0 |
| 规格： | 25 mg | 产品价格： | ￥1400.0 |
| 规格： | 50 mg | 产品价格： | ￥2200.0 |
| 规格： | 100 mg | 产品价格： | ￥3363.0 |
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Pergolide mesylate
CAS No. : 66104-23-2
MCE 国际站：Pergolide mesylate
产品活性：Pergolide mesylate (Pergolide methanesulfonate)，一种 Ergoline 衍生物，是一种有效的，具有口服活性的多巴胺 D1 和 D2 受体 (dopamine D1 和 D2 receptors) 激动剂。Pergolide mesylate 可用于帕金森氏病和高泌乳素血症的研究。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Dopamine Receptor
In Vitro: Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process.
In Vivo: Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance .
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文献和实验。乳汁产生与多种激素有关，在生长激素与皮质激素的协同作用下,雌激素促使乳腺腺管发育，而乳腺腺泡的发育则有赖雌、孕激素与PRL。乳蛋白(酪蛋白与乳白蛋白)与脂肪的合成主要由PRL调节,生长激素、胰岛素及皮质醇起促进作用。产后三个月,PRL水平降至正常值上限。而吸吮乳头可剌激PRL(分子量23 000)周期性释放以维持泌乳,并为下一次哺乳作准备。 高泌乳素血症病因 编辑本段 回目录 高泌乳素血症的发病原因多种多样，范围较广，可分为病理性、药理性和特发性三类
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