Mometasone furoate糠酸莫米松,83919-

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Mometasone furoate

CAS No. : 83919-23-7

MCE 国际站：Mometasone furoate

产品活性：Mometasone furoate (Sch32088) 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂，具有抗炎和抗过敏活性。Mometasone furoate 作为皮质类固醇类试剂，动物模型中，用于慢性皮肤湿疹和气道炎症以及哮喘的局部应用。

研究领域：GPCR/G Protein

作用靶点：Glucocorticoid Receptor

In Vitro: Mometasone furoate binds to a glucocorticoid receptor causes conformational changes in the receptor, separation from chaperones, and the receptor moves to the nucleus.
Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) strongly inhibits LPS-stimulated nitrite production in a concentration-dependent manner in J774 macrophages, The IC50 value is 0.00024 μM for Mometasone furoate in J774 cells.
Mometasone furoate (0.1-10 μM; 2h before LPS stimulation) is more potent than DEX, it significantly inhibits iNOS expression at a 0.01 µM concentration whereas Dex became active at 0.1 µM. Additionally, the inhibition of cox-2 protein expression at 0.01 μM is 79% for Mometasone furoate and 39% for Dex.

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