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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
733750-99-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥712.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥285.0 |
| 规格： | 5 mg | 产品价格： | ￥640.0 |
| 规格： | 10 mg | 产品价格： | ￥960.0 |
| 规格： | 25 mg | 产品价格： | ￥1600.0 |
| 规格： | 50 mg | 产品价格： | ￥2240.0 |
| 规格： | 100 mg | 产品价格： | ￥3440.0 |
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AR 231453
CAS No. : 733750-99-7
MCE 国际站：AR 231453
产品活性：AR 231453 是有效的、特异性的、具有口服活性的 GPR119 激动剂。AR 231453 可刺激细胞增殖，改善胰岛 β 细胞的功能。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：GPR119
In Vitro: AR 231453 is inactive at all other GPCRs tested (more than 230, including all known pancreatic islet receptors), indicating that it is highly selective for GPR119.
AR 231453 potently stimulats cAMP accumulation (EC50 = 4.7 nM) with a maximal efficacy similar to that seen with forskolin. AR 231453 significantly enhancesinsulin release in HIT-T15 cells, with an EC50 of 3.5 nM.
AR 231453 also stimulates insulin release in isolated mouse islets at glucose concentrations ranging from 8-17 mM.
In Vivo: AR231453 (20 mg/kg, orally) markedly improves oral glucose tolerance in a dose-dependent fashion, with efficacy similar to maximally effective doses of the sulfonylurea glyburide.
相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Orally Active Compound Library | Human Metabolite Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Activators Library | MBX-2982 | GSK1292263 | APD668 | 2-Oleoylglycerol | PSN632408 | AS1269574 | APD597 | PSN 375963 | Firuglipel | BMS-903452 | DPP-4/GPR119 modulator 1 | DPP-4/GPR119 modulator 2 | GPR119 agonist 2 | GSK1104252A | GSK2041706A
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Autosomal Recessive Juvenile Parkinsonism (AR-JP): Genetic Diagnosis
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