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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- CAS号：
1372540-25-4
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10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1192.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥1250.0 |
| 规格： | 10 mg | 产品价格： | ￥1880.0 |
| 规格： | 25 mg | 产品价格： | ￥3163.0 |
| 规格： | 50 mg | 产品价格： | ￥4400.0 |
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GSK2636771
CAS No. : 1372540-25-4
MCE 国际站：GSK2636771
产品活性：GSK2636771 是一种口服有效的选择性 PI3Kβ 抑制剂，Ki和IC50分别为0.89，5.2 nM，比p110α和p110γ的选择性高900倍，比p110δ同种型的选择性高10倍。
研究领域：PI3K/Akt/mTOR
作用靶点：PI3K
In Vitro: GSK2636771 treatment causes cell viability significantly more decreased in the control cells (p110β-reliant PTEN-deficient PC3 prostate and BT549 and HCC70 breast cancer cell lines) than in PTEN-mutant and PTEN wild-type EEC cells. Inhibition of p110β by GSK2636771 or AZD6482 leads to a marked decrease of AKT phosphorylation only in the control prostate and breast cancer cell lines, whereas only marginal effects on AKT activation are observed in EEC cells.
In Vivo: GSK2636771 is a p110β inhibitor, and the p110β primes cells for response to growth factor stimulation. While p110β inhibition suppresses cell and tumor growth, dual targeting of p110α/β enhances apoptosis and provides sustained tumor response in mice model.
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文献和实验kinase assays toward cdk2, cdk5, and25 other kinases (23) . Currently thiadiazolidinone (TDZD) isthe only ATP-noncompetitive inhibitor of GSK-3 (24) . While theexact mechanism by which TDZD inhibits GSK-3 kinase activityis unclear, it has been suggested
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
Measuring GSK3 Expression and Activity in Cells Methods in Molecular Biology v468. chapter 4 Abstract Glycogen synthase kinase (GSK)-3 is a key signalling intermediate in the action of Wnts. This protein kinaseis ubiquitously expressed
Mesoderm induction and dorso-ventral axial patterning TGF-β receptor (3) ; Xwnt-8 (4) ; Raf-1 (5) ; FGF receptor (6) ; FGF receptor/ activin (7) ; BMP (8) ; N-cadherin (9) ; GSK-3 (10) ; brachyury/pintallavis
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