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- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Sodium levothyroxine pentahydrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
6106-07-6
- 规格：
10 mM * 1 mL/500 mg/1 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥715.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥650.0 |
| 规格： | 1 g | 产品价格： | ￥850.0 |
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L-Thyroxine sodium salt pentahydrate
CAS No. : 6106-07-6
MCE 国际站：L-Thyroxine sodium salt pentahydrate
产品活性：L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) 是一种合成的甲状腺激素，用于甲状腺功能减退症的研究。DIO 酶将 L-Thyroxine (T4) 转化成具有生物活性的三碘甲状腺氨酸 (T3)。
研究领域：Others
作用靶点：Thyroid Hormone Receptor
In Vivo: Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03).
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文献和实验L-selectin-PNAd Interactions under Flow Conditions.
lower wall or expressed on a cell monolayer. The present protocol will focus on the interactions between L-selectin expressed on neutrophils and PNAd coated onto the plastic surface. For neutrophil purification see Purification of human
insulin, 5 μg/ml transferrin, 5 ng/ml sodium selenite, 20 ng/ml dexamethasone, 20 ng/ml l-thyroxine, 50 ng/ml bFGF, 100 ng/ml PDGF, and 20 ng/ml EGF. 4. Cells were grown either in plastic dishes or in dishes coated with 5 μg/cm2 fibronectin.
Deglycosylation of Glycoproteins Using Endoglycosidases
)6 Ovalbumin, high mannose, Sodium acetate, 100 mM, pH 5.8 Endo F2 Dansyl-L-M-G-E-N(CHO)-R Fibrinogen, biantennary Sodium acetate,100 mM, pH 4.5 Endo F3 Tridansyl-Y-K-N
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