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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
SC 204330
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
491871-58-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥507.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥283.0 |
| 规格： | 5 mg | 产品价格： | ￥627.0 |
| 规格： | 10 mg | 产品价格： | ￥1004.0 |
| 规格： | 25 mg | 产品价格： | ￥2000.0 |
| 规格： | 50 mg | 产品价格： | ￥3000.0 |
| 规格： | 100 mg | 产品价格： | ￥4500.0 |
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TCS PIM-1 1
CAS No. : 491871-58-0
MCE 国际站：TCS PIM-1 1
产品活性：TCS PIM-1 1 (SC 204330) 是一种有效的，具有选择性和 ATP 竞争性的 Pim-1 激酶抑制剂，IC50 为 50 nM，对 Pim-2 和 MEK1/MEK2 表现出良好的选择性 (IC50 >20000 nM)。
研究领域：JAK/STAT Signaling
作用靶点：Pim
In Vitro: TCS PIM-1 1 (compound 1), a substituted pyridone scaffold, binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2. Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein.
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From In Vitro to In Vivo: Imaging from the Single Cell to the Whole Organism
) Thermoregulated Lucite chamber (Vestavia Scientific) Confocal microscope system (e. g., Leica TCS SP2, Leica Microsystem
（2）CTL的识别机制：多种粘附分子参与CTL对靶细胞的识别和粘附，主要有：①LFA-1/ICAM-1、ICAM-2、ICAM-3，可溶性ICAM-1（sICAM-1）可抑制CTL杀伤肿瘤细胞；②CD2/LFA-3（CD58），抗CD2McAb或抗CD58 McAb均可抑制CTL效应细胞对靶细胞的杀伤；③CD8/MHc I类抗原的非多态性结构域。 （3）CTL的杀伤机制：TCL杀伤靶细胞的机理目前认为主要通过释放多种的介质和因子介导的。 ①穿孔素（perforin）:又称成孔蛋白
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