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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, protect from light
- 英文名：
Bay-09867
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
85721-33-1
- 规格：
500 mg/1 g/5 g
| 规格： | 500 mg | 产品价格： | ￥350.0 |
|---|---|---|---|
| 规格： | 1 g | 产品价格： | ￥400.0 |
| 规格： | 5 g | 产品价格： | ￥800.0 |
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Ciprofloxacin
CAS No. : 85721-33-1
MCE 国际站：Ciprofloxacin
产品活性：Ciprofloxacin (Bay-09867) 是一种口服有效的拓扑异构酶 IV 抑制剂。Ciprofloxacin 诱导线粒体 DNA 和核 DNA 损伤并导致线粒体功能障碍和活性氧产生。Ciprofloxacin 具有抗增殖活性并诱导细胞凋亡 (apoptosis)。Ciprofloxacin 是一种氟喹诺酮类抗生素，具有强大的抗菌活性。
研究领域：Cell Cycle/DNA Damage | Apoptosis | Anti-infection | Metabolic Enzyme/Protease | NF-κB | Immunology/Inflammation
作用靶点：Topoisomerase | Apoptosis | Antibiotic | Bacterial | Mitochondrial Metabolism | Reactive Oxygen Species
In Vitro: Ciprofloxacin (Bay-09867) (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase.
?Ciprofloxacin (Bay-09867) shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively.
In Vivo: Ciprofloxacin (Bay-09867) (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague.
?Ciprofloxacin (Bay-09867) (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall.
?Ciprofloxacin (Bay-09867) (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall.
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文献和实验这在我们实验室是不可能使用的方法；有些文章是联合使用两种抗生素来清除支原体，简单方便，我就试了这种。 关于检验支原体污染，有PCR法、培养法、DNA荧光染色法，我选择的是DNA荧光染色法，将冰醋酸和甲醇按1:3混合，固定细胞两次，每次10分钟，然后用1μg/ml的Hoechst33258染色20分钟，紫外激发，确认了我的细胞中生长最好的都有支原体污染。于是我花1.5元买了环丙沙星（ciprofloxacin）药片，稀释成50μg/ml，离心去除淀粉之类的不溶性辅料，加入培基中，稀释成10μg/ml，跟正常
Protocol for a Facile Multiplex PCR for Multi-antimicrobial Resistance and Gonococcus Detection
of the antimicrobial-resistant profile. By this method, penicillinase-producing Neisseria gonorrhoeae (PPNG), high-level tetracycline-resistant N. gonorrhoeae (TRNG), and ciprofloxacin-resistant N. gonorrhoeae (CRNG) can be clearly identified. Moreover, the plasmid
to this early nonfluormated quinolone are susceptible to the action of the newer fluoroquinolones. The fluoroquinolones, such as ciprofloxacin and ofloxacin, have proved to be potent antimicrobials and are used throughout the world in the treatment of bacterial
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