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- 详细信息
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名:
MK-422
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- 规格:
10 mM * 1 mL/50 mg/100 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥453.0 |
|---|---|---|---|
| 规格: | 50 mg | 产品价格: | ¥412.0 |
| 规格: | 100 mg | 产品价格: | ¥612.0 |
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Enalaprilat dihydrate
CAS No. : 84680-54-6
MCE 国际站:Enalaprilat dihydrate
产品活性:Enalaprilat dihydrate (MK-422) 是口服前体 Enalapril 的活性代谢物,是一种有效,竞争性和长效的血管紧张素转换酶 (ACE) 抑制剂,IC50 值为 1.94 nM。Enalaprilat dihydrate 可用于高血压的研究。
研究领域:Metabolic Enzyme/Protease
作用靶点:Angiotensin-converting Enzyme (ACE)
In Vitro: Enalaprilat (1 nM-10 μM; 24 h) dihydrate attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM.
In Vivo: Enalaprilat (0.01%-2.9% in the eyedrop solution) dihydrate shows significant intraocular pressure (IOP)-lowering effect in rabbits.
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