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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
TAK-375
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
196597-26-9
- 规格：
10 mM * 1 mL/500 mg/2 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥495.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥ |
| 规格： | 2 mg | 产品价格： | ￥180.0 |
| 规格： | 5 mg | 产品价格： | ￥450.0 |
| 规格： | 10 mg | 产品价格： | ￥800.0 |
| 规格： | 50 mg | 产品价格： | ￥2200.0 |
| 规格： | 100 mg | 产品价格： | ￥3200.0 |
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Ramelteon
CAS No. : 196597-26-9
MCE 国际站：Ramelteon
产品活性：Ramelteon 是一种强效、高选择性和具有口服活性的 MT1/MT2 激动剂，Ki 值分别为 14 和 112 pM。Ramelteon 具有研究失眠症的潜力。Ramelteon长期使用持续减少睡眠发作，停药后无翌日晨残留效应或反弹性失眠或戒断症状。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Melatonin Receptor
In Vivo: Ramelteon (p.o.; 0.1 and 1 mg/kg) accelerates reentrainment of running wheel activity rhythm to the new lightdark cycle.
Ramelteon (p.o.; 3, 10, and 30 mg/kg) does not affect learning or memory in rats tested by the water maze task and the delayed match to position task, implying that MT1/MT2 receptor agonists have no abuse potential.
Ramelteon (0.0001, 0.001, 0.01, and 0.1 mg/kg; p.o.; 8 hours) significantly decreases wakefulness at doses of 0.001, 0.01, and 0.1 mg/kg, increases slow-wave sleep at doses of 0.001, 0.01, and 0.1 mg/kg, and increases rapid eye movement sleep at a dose of 0.1 mg/kg.
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