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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
R165335; TMC125
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
269055-15-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1134.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥598.0 |
| 规格： | 10 mg | 产品价格： | ￥996.0 |
| 规格： | 25 mg | 产品价格： | ￥1818.0 |
| 规格： | 50 mg | 产品价格： | ￥2727.0 |
| 规格： | 100 mg | 产品价格： | ￥3818.0 |
| 规格： | 200 mg | 产品价格： | ￥5350.0 |
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Etravirine
CAS No. : 269055-15-4
MCE 国际站：Etravirine
产品活性：Etravirine 是一种非核苷逆转录酶抑制剂 (NNRTI)，具有抗 HIV 的作用。
研究领域：Anti-infection
作用靶点：Reverse Transcriptase | HIV
In Vitro: TMC125 is highly active against wild-type HIV-1 (50% effective concentration [EC50]=1.4 to 4.8 nM) and shows some activity against HIV-2 (EC50=3.5 μM). TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus. TMC125 has activity for 19 viruses with EC50 of < 5 nM.
In Vivo: Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group.
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