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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
371942-69-7
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1100.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥550.0 |
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1700.0 |
| 规格： | 25 mg | 产品价格： | ￥3200.0 |
| 规格： | 50 mg | 产品价格： | ￥4800.0 |
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YM-201636
CAS No. : 371942-69-7
MCE 国际站：YM-201636
产品活性：YM-201636 是高效选择性的 PIKfyve 抑制剂，IC50 值为 33 nM。YM-201636 也抑制 p110α，IC50 为 3.3 μM。YM-201636 可抑制逆转录病毒复制。
研究领域：PI3K/Akt/mTOR | Autophagy | Anti-infection
作用靶点：PIKfyve | PI3K | Autophagy | Influenza Virus
In Vitro: Acute treatment of cells with YM-201636 shows that the PIKfyve pathway is involved in the sorting of endosomal transport, with inhibition leading to the accumulation of a late endosomal compartment and blockade of retroviral exit. The yeast orthologue of PIKfyve, Fab1, is found to be insensitive to YM-201636 (IC50>5 μM). YM-201636 does not inhibit a type IIγ PtdInsP kinase even at 10 μM and inhibits a mouse type Iα PtdInsP kinase with an IC50>2 μM. YM-201636 almost completely inhibits basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC50=54 nM for the net insulin response. YM-201636 also completely inhibits insulin-dependent activation of class IA PI 3-kinase. At low doses (10-25 nM), YM-201636 inhibits preferentially PtdIns5P rather than PtdIns(3,5)P2 production, whereas at higher doses, the two products are similarly inhibited. YM-201636 at 160 nM inhibits PtdIns5P synthesis twice more effectively compared with PtdIns(3,5)P2 synthesis. MDCK cells treated with YM-201636 accumulate the tight junction protein claudin-1 intracellularly. YM-201636 treatment blocks the continuous recycling of claudin-1/claudin-2 and delays epithelial barrier formation.
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文献和实验of a novel curcumin analog P1 as potent inhibitor of the NF-κB signaling pathway with distinct mechanisms. 作者：Peng YM, Zheng JB, Zhou YB, Li J. Aim:Curcumin has shown promising anticancer activity, which relies on its inhibition on NF-κB pathway
+e/MNcTXL5n8RmjoNHFCGBSf86HgcNl/Q/zf9vuKyPEgIvCGIxBJ8hsOacwwIhARiAhEBA5UBGqNqjWbdW1mtUrdyV+jXk1IYEMn4YM6nZDCutWqZR00rFzudxJZrSqt4jQGeGGlUkryU5yQd5U0nklDZ5tWqlZMJVhFW83qOrc7ruczQEBdHsWhjLryr9ZrXmZDaSCw5F9t1K2/UvY8KjXK0f+qSqEA8vGfJC77lUpFoiAsldKmPBG+r
G0/G1 S Control 9.31±0.24 62.91±1.30 33.77±0.41 0.5μmol/L As2O3 15.53±0.69 60.92±2.16 36.87±2.46 1μmol/L As2O3 19.10±1.02a 57.55±2.24 40.14±2.87 2μmol/L As2O3 21.87±0.84a 54.12±1.18 43.17±
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