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- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1021868-92-7
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1089.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥618.0 |
| 规格： | 10 mg | 产品价格： | ￥990.0 |
| 规格： | 50 mg | 产品价格： | ￥3800.0 |
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ZM39923 hydrochloride
CAS No. : 1021868-92-7
MCE 国际站：ZM39923 hydrochloride
产品活性：ZM39923 hydrochloride 是一种 JAK3 抑制剂， pIC50 值为 7.1；ZM39923 hydrochloride 同时可抑制组织型转谷氨酞胺酶 (TGM2) 的活性，IC50 值为 10 nM。
研究领域：Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt
作用靶点：JAK
In Vitro: ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC50, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0). ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca2+ activated form of TGM2. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells.
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material using recombinant PCR. Biotechniques. 1999;27(6):1180-1186. [PubMed] Chrzanowska-Lightowlers ZM, Temperley RJ, McGregor A, Bindoff LA, Lightowlers RN. Conversion of a reporter gene for mitochondrial gene expression using iterative mega-prime
Promoter analysis by saturation muta
. Biotechniques. 1991;10(4):489-490. [PubMed] Blattner FR. Direct amplification of the entire ITS region from poorly preserved plant material using recombinant PCR. Biotechniques. 1999;27(6):1180-1186. [PubMed] Chrzanowska-Lightowlers ZM
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