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- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
210344-95-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4487.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1050.0 |
| 规格： | 5 mg | 产品价格： | ￥3050.0 |
| 规格： | 10 mg | 产品价格： | ￥4435.0 |
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Z-DEVD-FMK
CAS No. : 210344-95-9
MCE 国际站：Z-DEVD-FMK
产品活性：Z-DEVD-FMK 是一种特异性的不可逆的 caspase-3 抑制剂，IC50 为 18 μM。
研究领域：Apoptosis
作用靶点：Caspase
In Vitro: N27 cells are exposed to MPP+ in the absence or presence of 50 μM Z-DIPD-FMK or 100 μM Z-DEVD-FMK or 50 μM Z-LEHD-FMK and then caspase-9 and caspase-3 enzymatic activities are determined by enzymatic assay at 12 and 24 h following exposure, respectively. Exposure to 300 μM MPP+ for 24 h in N27 cells results in an approximately 2.5-fold increase in caspase-3 enzyme activity. MPP+-induced increases in caspase-3 enzyme activity are significantly blocked by 50 μM Z-DIPD-FMK, 100 μM Z-DEVD-FMK, and 50 μM Z-LEHD-FMK.
In Vivo: Early Z-DEVD-FMK (160 ng) treatment improves motor and cognitive function after traumatic CNS injury induced by severe controlled cortical impact (CCI) in the mouse. Treatment with Z-DEVD-FMK (160 ng) significantly improves neurological outcome when compared with traumatized animals treated with DMSO vehicle (p<0.01).
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文献和实验【求助】请教Z-VAD, Ac—DEVD—CHO和Z-Asp-crnk
fenghaozi 请教Z-VAD, Ac—DEVD—CHO和Z-Asp-crnk的中文名称各是什么 另外他们之间有何关系 作为对Caspase-3的抑制剂来讲，选择哪种最好？标准是什么？ 请教高手回答，谢谢 ioz2008sina Caspase抑制剂Z-VAD-FMK(Caspase Inhibitor Z-VAD-FMK)是一种可以穿透细胞膜的泛Caspase抑制
Here, we describe a nanocarrier system that can transfer chitosan nanoparticles loaded with either small peptides such as the caspase inhibitor Z-DEVD-FMK or a large peptide like basic fibroblast growth factor across the blood–brain barrier
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