- ￥1250 - 6500
- MedChemExpress(MCE)
- 美国
- HY-12451
- 2025年07月13日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
6-Formylindolo[3,2-b]carbazole
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
172922-91-7
- 规格：
10 mM * 1 mL/50 mg/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3909.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | 询价 |
| 规格： | 1 mg | 产品价格： | ￥1250.0 |
| 规格： | 5 mg | 产品价格： | ￥4750.0 |
| 规格： | 10 mg | 产品价格： | ￥6500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
FICZ
CAS No. : 172922-91-7
MCE 国际站：FICZ
产品活性：FICZ是有效的芳烃受体 (AhR) 激动剂，Kd值为70 pM。
作用靶点：Aryl Hydrocarbon Receptor
In Vitro: FICZ (0.01 nM-1 µM) alone or in combination with 50 nM MNF induces sustained CYP1A1 activity and leads to oxidative stress and activation of apoptosis via a mitochondrial-dependent pathway. In HepG2 cells, FICZ stimulates cell growth at low concentrations but inhibits cell growth at high concentrations. FICZ (10,000-30,000 nM) significantly decreases CEH viability with an estimated LC50 (95% confidence intervals) of 14,000 nM. FICZ shows concentration-dependent effects on EROD activity in CEH cultures, with the mean EC50 values at 3, 8, and 24 h of 0.016 nM, 0.80 nM, and 11 nM, respectively. FICZ treatment increases transcript expression of CYP1A1 in a dose-dependent manner in both the parental iPSC line and the CYP1A1 targeted clone. CYP1 inhibition in the presence of FICZ results in enhanced AHR activation, suggesting that FICZ accumulates in the cell when its metabolism is blocked. CYP1 enzymes plays a role in regulating biological effects of FICZ.
Nuclear export and degradation of the AHR protein are two additional steps in the AHR-mediated signal transduction pathway.
Exposure to AhR agonists causes AhR-expressing cells to downregulate the receptor through the ubiquitin/proteasome degradation pathway.
相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Oxygen Sensing Compound Library | Transcription Factor-Targeted Library | Osteogenesis Compound Library | Cysteine Targeted Covalent Library | PD98059 | CH-223191 | Pifithrin-α hydrobromide | L-Kynurenine | Tapinarof | StemRegenin 1 | ITE | BAY 2416964 | Diosmin | Indole-3-carbinol | Carbidopa | GNF351 | VAF347 | BAY-218 | Indole-3-pyruvic acid | Skatole | PDM2 | β-Naphthoflavone | AHR antagonist 2 | Benzyl butyl phthalate | AHR antagonist 5 | 1,4-Chrysenequinone | YL-109 | 6,2',4'-Trimethoxyflavone | D-Kynurenine | AhR agonist 2 | Brevifolincarboxylic acid | CAY 10465 | KYN-101
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Th17 Polarization of Mouse CD4 Cells
-dibutyrate)[Details: Sigma, cat.#P1269] FICZ (6-formylindolo[3,2-b]carbazole)[Details: Life Sciences, cat. #BML-GR206-0100] 实验步骤 1. Isolation of CD4 cells from lymph nodes 1) Harvest lymph nodes (superfical cervical
技术资料暂无技术资料 索取技术资料
