- ￥1200 - 5500
- MedChemExpress(MCE)
- 美国
- HY-12438
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1380672-07-0
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1399.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥2000.0 |
| 规格： | 25 mg | 产品价格： | ￥3800.0 |
| 规格： | 50 mg | 产品价格： | ￥5500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
G007-LK
CAS No. : 1380672-07-0
MCE 国际站：G007-LK
产品活性：G007-LK 是一种有效的，选择性的 TNKS1 和 TNKS2 抑制剂，IC50值分别为 46 nM 和 25 nM。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：PARP
In Vitro: G007-LK is a potent inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively, and a cellular IC50 of 50 nM. G007-LK shows no inhibition of PARP1 at doses up to 20 μM, and has a high CYP3A4 inhibition IC50 value (>25 μM). G007-LK (0-20 μM) dose-dependently inhibits hepatocellular carcinoma (HCC) cell growth. G007-LK also downregulates the levels of YAP by upregulating AMOTL1 and AMOTL2 in HCC cell lines. In addition, G007-LK (0-20 μM) synergizes with MEK and AKT inhibitors to suppress HCC cell proliferation.
In Vivo: G007-LK displays great pharmacokinetic profile in ICR mice. G007-LK (100 mg/kg chow, p.o.) significantly reduces lineage tracing from LGR5+ intestinal stem cells in mice. G007-LK (100 mg/kg chow, p.o.) specifically targets LGR5+ WNT-dependent intestinal stem cells in Lgr5-EGFP-CreERT2;R26R-tdTomato mice. G007-LK (10, 50 mg/kg, p.o.) also suppressses canonical WNT signalling. Furthermore, G007-LK (100, 1000 mg/kg chow, p.o) shows no effect on the alteration of duodenal morphology.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Targeted Diversity Library | Highly Selective Inhibitors Library | Olaparib | XAV-939 | Talazoparib | Niraparib | Saruparib | Rucaparib | Veliparib | PJ34 | Chlorin e6 | Pamiparib | RBN-2397 | Fucosterol | Dehydrocorydaline | Fluzoparib | RBN012759 | 3-Aminobenzamide | AG14361 | Patritumab | Daphnetin | NVP-TNKS656 | Rucaparib monocamsylate | AZD-2461 | EB-47 dihydrochloride | Iniparib | Paris saponin VII
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验【公告】本版2009全年牛贴牛人大盘点 进入发帖、得分排行榜的战友跟帖领分
:34 标题: 【求助】谁能给讲讲封闭的原理？ URL: http://www.dxy.cn/bbs/post/view?bid=65&id=15201822 点击: 5195 作者: crisycheng 发帖时间: 2009-07-28 19:54:44 标题: 【转帖】Sharing：Western Blot 图片灰度分析 photoshop ImageJ URL: http://www.dxy.cn/bbs/post/view?bid=65&id=15969909
7Az/y1EevzuWQnfVqCX4LfP78GTNnzcKM6dNRuHDhBLdPCw0eP3qEzh06IsyRLuyXt/jKU1ZRgaqqKtTU1aGpqQEtrSzIkiULtLWzIZeODgoVKgQTExOUKl0axYoVk+qmhTUpYg6fbTZirXDpUVajpL76MG07lo5IhqJRXmFFGiZ8+MHjkwuU1OiSLBi/hbWpUjC83dzxO7gINERVldwwm38O19udxrHjtrh6/RZOWd2lx1JAswS
07UvZi8YGNKktzPSb8+5NCp7qqQCZJDh4jUaqIgJJv7DmyeevoJXzxG/Eg2riJYstN9//s+6HhBsGkr7hMIPX2XtuelZPLkyU7oaSfqSf2Ix7OO9gFTCDt9hPqEe4z+QjxwIA5xIYPkkdY50uMfuF33CO0OieaZpewdV54D4aWAexSiDsa4zdugfj150hR/Jt74sxv8ucFzEzIO+e0czheylf71bPbRM+zBuxba5DEoFZKXXvU29UU9F9T
技术资料暂无技术资料 索取技术资料
