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- MedChemExpress(MCE)
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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CGP42112A
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
127060-75-7
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥ |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥997.0 |
| 规格： | 5 mg | 产品价格： | ￥3745.0 |
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CGP-42112
CAS No. : 127060-75-7
MCE 国际站：CGP-42112
产品活性：CGP-42112(CGP-42112A)是血管紧张素受体AT2激动剂。
研究领域：GPCR/G Protein
作用靶点：Angiotensin Receptor
In Vitro: CGP-42112 (≥1 nM) significantly inhibits cGMP production from the basal value. CGP-42112 (≥1 nM) significantly inhibits TH-enzyme activity from the basal value. These inhibitory effects of CGP-42112 on TH-enzyme activity and-cGMP production are abolished by PD123319 (AT(2)-R antagonist) while CV-11974 (AT(1)-R antagonist) is ineffective. [125I]CGP-42112 binds selectively to the AT2 angiotensin II receptor subtype. [125I]CGP-42112 binds with higher affinity in the brain than in the adrenal. beta-Mercaptoethanol enhanced [125I]CGP-42112 binding in the brain, but does not alter its binding in the adrenal. [125I]CGP-42112 binds with high affinity (Kd = 0.07-0.3 nM, depending on the area studied). [125I]CGP-42112 binding is selective for AT2 receptors, as determined by lack of competition with the AT1 ligand losartan, and competition by the AT2 ligands PD 123177 and unlabeled CGP-42112 and the non-selective peptides Ang II and angiotensin III (Ang III).
In Vivo: Intravenous infusions of CGP-42112 (0.1 and 1 mg kg-1 min-1) and PD 123319 (0.36 and 1 mg kg-1 min-1) shifted the upper limit of CBF autoregulation toward higher blood pressures without affecting baseline CBF.
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文献和实验时间：10～14小时。 全血粒细胞池（TBGP）：35～70×107/kg 循环粒细胞池（CGP）：20～30×107/kg 边缘粒细胞池（MGP）：15～40×107/kg 粒细胞周转率（GTR）：60～160×107/（kg？d） 66.粒细胞抗体检测 正常时血清阴性（萤光免疫法） 67.白细胞抗人球蛋白消耗试验 如测定组效价低于标准对照组2管或2管以上为阳性，表明受检血清中有不完全抗粒细胞抗体。正常对照和盐水对照组应无消耗
Characterization of Wild‐Type Excitatory Amino Acid Ion Channel Receptors
.1 rotors, or equivalent) 12 × 75–mm borosilicate glass tubes or 1.5‐ml polypropylene tubes (for filtration assays) Vacuum
Characterization of Angiotensin II Receptors
liver. Biochem. Pharmacol. 46:1653‐1660. Johren, O., Viswanathan, M., and Saavedra, J.M. 1995. Expression of the non‐angiotensin II I‐125*CGP‐42112 binding sites on activated
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