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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1097.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥850.0 |
| 规格： | 5 mg | 产品价格： | ￥997.0 |
| 规格： | 10 mg | 产品价格： | ￥1950.0 |
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GSK2194069
CAS No. : 1332331-08-4
MCE 国际站：GSK2194069
产品活性：GSK2194069 是脂肪酸合成酶 (FASN) 的 β-酮基还原酶 (KR) 的有效抑制剂，IC50 为 7.7 nM。GSK2194069 通过作用乙酰乙酰辅酶 A、NADPH (IC50 或 Ki 分别为 4.8 nM 和 5.6 nM) ，抑制表达 FAS 的癌细胞。
研究领域：Metabolic Enzyme/Protease
作用靶点：Fatty Acid Synthase (FASN)
In Vitro: GSK2194069 (100 nM; 24 h) inhibits fatty acid synthase (FAS) in cancer cell lines (KATO-III, MKN45, A549, SNU-1) without reducing FAS production protein level.
GSK2194069 decreases phosphatidylcholine levels in A549 cells with a half-maximum effective concentration (EC50) value of 15.5 ± 9 nM (n = 78), correlating with the decreased palmitate synthesis.
GSK2194069 (5 μM and 20 μM) shows higher efficacy in FASN-positive LNCaP cells rather than FASN-negative PC3 cells, with the higher FASN Expression level in LNCaP cells.
GSK2194069 (50 μM; 24 h) inhibits the growth of LNCaP-LN3 human prostate cancer cells.
GSK2194069 (60.4 nM; 24 h) displays properties of metabolomics, including L-acetyl carnitine, stearoyl carnitine, vaccenyl carnitine, and palmitoyl-L-carnitine decrease in LNCaP-LN3 cells.
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