OAC1,300586-90-7

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OAC1

CAS No. : 300586-90-7

MCE 国际站：OAC1

产品活性：OAC1 是一种有效的 Oct4 激活剂。OAC1 激活 Oct4 和 Nanog 启动子，促进诱导多功能干细胞 (iPSC) 的形成。OAC1 通过上调 HOXB4 表达激活 OCT4。OAC1 增加了 Oct4-Nanog-Sox2 三联体和 TET1 的转录。OAC1 通过提高效率和缩短重编程时间，促进了细胞的重编程。

研究领域：Stem Cell/Wnt  |  Epigenetics

作用靶点：Oct3/4  |  TET Protein

In Vitro: OAC1 (10 μM; 7 d) enhances reprogramming efficiency. OAC1 increases induced pluripotent stem cells (iPSC) generation from mouse embryonic fibroblasts (MEFs) and accelerates the appearance of iPSC-like colonies.
OAC1 (1 µM; 2 d; human IMR90 fibroblast cells) activates endogenous Oct4, Nanog, Sox2, and Tet1 expression.
OAC1 (500 nM; 4 d; CD34⁺ cells) increases numbers of phenotypic hematopoietic stem cells (HSC) and functional Hematopoietic progenitor cells (HPC).
OAC1 (500 nM; 4 d; CD34⁺ cells) activates OCT4 through upregulation of HOXB4 expression to expand hematopoietic stem cells (HSC).

In Vivo: OAC1 (50000 CB CD34⁺ cells with OAC1(500 nM); i.h.; 16 weeks) enhances short and long-term engrafting hematopoietic stem cells (HSC) in irradiated NSG mice.

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