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- MedChemExpress(MCE)
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- 2025年12月05日
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- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
NVP-AAM077 tetrasodium hydrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1479.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥545.0 |
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥2000.0 |
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PEAQX tetrasodium hydrate
MCE 国际站：PEAQX tetrasodium hydrate
产品活性：PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂，其对 hNMDAR 1A/2A 和 hNMDAR 1A/2B 的 IC50 值分别为 270 nM 和 29600 nM。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Apoptosis
In Vitro: PEAQX (3 μM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent.
In Vivo: PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration.
?PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F3, 73=4.99).
?PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment.
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