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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- CAS号：
1206711-16-1
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10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥957.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥246.0 |
| 规格： | 5 mg | 产品价格： | ￥543.0 |
| 规格： | 10 mg | 产品价格： | ￥870.0 |
| 规格： | 25 mg | 产品价格： | ￥1820.0 |
| 规格： | 50 mg | 产品价格： | ￥2910.0 |
| 规格： | 100 mg | 产品价格： | ￥4520.0 |
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DMH-1
CAS No. : 1206711-16-1
MCE 国际站：DMH-1
产品活性：DMH-1 是一种有效的，具有选择性的 BMP 抑制剂，对 ALK1/ALK2/ALK3/ALK6的IC50 值分别为 27/107.9/<5/47.6 nM。
研究领域：Autophagy | TGF-beta/Smad
作用靶点：Autophagy | TGF-β Receptor
In Vitro: DMH-1 (0.5 μM) induces regulation of OCT4, Nanog, and PAX6 protein expression. DMH-1 significantly reduces the percentage of cells expressing the pluripotency marker proteins OCT4 and Nanog in both SM3 and CA6 cells. PAX6 expression is significantly up-regulated by day 5 and day 7 in CA6 and SM3 cells, respectively. DMH-1 induces regulation of pluripotency and neural precursor marker mRNAs. PAX6 can regulate the expression of SOX1 independently by manipulating the DMH-1 concentration during the neural induction of hiPSCs. DMH-1 (5 μM and 10 μM) inhibits CDDP-induced autophagy in HeLa cells and enhances the ability of CDDP to reduce HeLa cell viability, inhibits tamoxifen-induced autophagy in MCF-7 cells and enhances the ability of Tamoxifen (HY-13757A) to reduce MCF-7 cell viability, inhibits 5-FU-induced autophagy in both MCF-7 and HeLa cells but does not affect the inhibitory effects of 5-FU on MCF-7 and HeLa cell viability. DMH-1 enhances the apoptotic induction effects of CDDP on HeLa cells after 24 h treatment. DMH-1 inhibits HeLa and MCF-7 cell proliferation. DMH-1 (20 μM) reduces the canonical phosphorylation of Smads 1,5 and 9. DMH-1 in combination with Cisplatin significantly decreases Ki-67 positive staining in the OVCAR8 cells. DMH-1 (20 μM) upregulates JAG1, reduces CYP1B1 and increases HAPLN1 expression in both OVCAR8 and NCI-RES cells.
In Vivo: DMH1 (5 mg/kg, i.p.) treatment significantly reduces the tumor growth in human lung cancer xenograft model.
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文献和实验起来则可以高通量进行甲基化的定性、定量分析。 目前建立了2种基于芯片的甲基化分析方法：一个是甲基化特异寡核苷酸芯片(methylation specific oligonucleotide arrays，MSO)方法，另一个是差异甲基化杂交法(differential methylation hybridization method，DMH)。第一种方法利用直接杂交原理，只是在标记前先用亚硫酸氢钠处理DNA，从而使所有未甲基化的胞嘧啶转变为尿嘧啶，而甲基化的胞嘧啶并不受该处
1，1-dimethylhydrazine，DMH)，为白色粉状结晶， 每次临注射前以无菌生理盐水配成0.4％溶液，并用NaHCO3将其pH调至6.5-7.0。每周给小鼠颈部皮下注射DMH 20mg/kg(即0.4％DMH溶液0.05ml/10g)一次， 连续20(或16)次。 于注射日起6(或5) 个月末处死动物，检查大肠的肿瘤。据资料报导，大肠癌的发病率为81-100％。诱发的大肠肿瘤均系恶性肿瘤。肿瘤发生在肠壁的粘膜面，大多向肠内突出，肿瘤表面光滑，少数有糜烂。全部肿瘤均分布在距肛门6.5cm范围内，以距肛门3-4cm处最密集
2.2.10 DNA微阵列法 Yan等2001年[40]将以分子杂交为基础的微阵列技术应用于DNA甲基化检测中，这种方法是基于杂交的寡核苷酸微阵列，是一种在基因组中寻找新位点的方法。包括用于整个基因组范围内扫描的差异甲基化（DMH）杂交（Huang等1999年[41]）和用于检测某个位点的甲基化特异性微阵列MSO（Gitan等2002年[42]）。前者类似于mRNA表达谱或cDNA微阵列，是CpG岛微阵列，后者类似于寡核苷酸微阵列，是针对CpG二核苷酸位点的甲基化特异性寡核苷酸微阵列[26
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