Capsaicin辣椒素,404-86-4

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Capsaicin

CAS No. : 404-86-4

MCE 国际站：Capsaicin

产品活性：Capsaicin ((E)-Capsaicin) 是辣椒中的活性成分，是一种 TRPV1 激动剂。Capsaicin 具有减轻疼痛、抗氧化、抗炎、神经保护和抗癌作用。

研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Autophagy | Apoptosis | Metabolic Enzyme/Protease

作用靶点：TRP Channel | Autophagy | Apoptosis | Endogenous Metabolite

结构分类：酚类 | 单酚类

来源：植物 | 茄科 | 辣椒

In Vitro: Capsaicin (50-300 µM; 24-72 hours) shows an augmented decrease in cell growth in a dose- and time-dependent manner. The observed IC50 value is around 150 µM.
Capsaicin (50-300 µM; 24-72 hours) shows increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels, and decreases anti-apoptotic Bcl-2 protein and increases pro-apoptotic Bad/Bax expression.
Capsaicin increases the nuclear condensation, nuclear DNA fragmentation and sub-G1 DNA content.
Capsaicin suppresses the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4.

In Vivo: Capsaicin suppresses the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3.

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