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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
AZD2811; INH-34; AZD1152-HQPA
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
722544-51-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥726.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥295.0 |
| 规格： | 5 mg | 产品价格： | ￥650.0 |
| 规格： | 10 mg | 产品价格： | ￥860.0 |
| 规格： | 25 mg | 产品价格： | ￥1740.0 |
| 规格： | 50 mg | 产品价格： | ￥2870.0 |
| 规格： | 100 mg | 产品价格： | ￥5000.0 |
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Barasertib-HQPA
CAS No. : 722544-51-6
MCE 国际站：Barasertib-HQPA
产品活性：Barasertib-HQPA (AZD2811) 是一种高度选择性的极光激酶B抑制剂，在非细胞试验中 IC50 值为0.37 nM。Barasertib-HQPA (AZD2811) 对可引起癌细胞生长阻滞和凋亡。
研究领域：Cell Cycle/DNA Damage | Epigenetics | Apoptosis
作用靶点：Aurora Kinase | Apoptosis
In Vitro: Barasertib-HQPA (3 μM, 3 hours) significantly decreases expression of the phosphorylated forms of histone H3 in freshly isolated leukemia cells.
?Barasertib-hydroxyquinazoline pyrazol anilide (HQPA) is converted rapidly to the active Barasertib-HQPA in plasma.
?Barasertib-HQPA treatment induced defective cell survival, polyploidy, and cell death in LNCaP cell line.
?Barasertib-HQPA induces a marked anti-propliferative effect accompanied by the appearance of a polyploid population, which in most cases led to apoptosis.
In Vivo: Barasertib-HQPA (AZD1152, 25 mg/kg) markedly suppresses the growth and weights of AZD1152-treated tumors.
?Barasertib-HQPA (AZD1152, 5 mg/kg) enhances the ability of vincristine or daunorubicin to inhibit the proliferation of human MOLM13 leukemic xenografts.
?Barasertib-HQPA (AZD1152, (10-150 mg/kg/d) potently inhibited the growth of human colon, lung, and hematologic tumor xenografts (mean tumor growth inhibition range, 55% to z100%; P < 0.05) in immunodeficient mice.
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