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- 2025年07月14日
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4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
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- CAS号：
173897-44-4
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5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 5 mg | 产品价格： | ￥729.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥1233.0 |
| 规格： | 25 mg | 产品价格： | ￥2870.0 |
| 规格： | 50 mg | 产品价格： | ￥4590.0 |
| 规格： | 100 mg | 产品价格： | ￥7340.0 |
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Y-33075 dihydrochloride
CAS No. : 173897-44-4
MCE 国际站：Y-33075 dihydrochloride
产品活性：Y-33075 dihydrochloride是选择性的 ROCK 抑制剂，IC50 为 3.6 nM。
研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | Cytoskeleton | TGF-beta/Smad
作用靶点：ROCK
In Vitro: Y-33075 (Y-39983) is a potent ROCK inhibitor, with an IC50 of 3.6 nM. Y-33075 also inhibits PKC and CaMKII more potently than Y-27632, and the IC50s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively, whereas the IC50s of Y-27632 and Y-33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC50s of Y-27632 and Y-33075 for PKC is 82 and 117 times those for ROCK, respectively, whereas the IC50s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively. Y-33075 (Y-39983, 10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983. Y-33075 (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca2+-free solutions. Y-33075 (10 μM) shows no effect on the [Ca2+]i increase with the high-potassium (high-K) solution.
In Vivo: In rabbits, Y-39983 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration. In monkeys, Y-39983 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration. Y-39983 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Stem Cell Signaling Compound Library | TGF-beta/Smad Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Reprogramming Compound Library | Cytoskeleton Compound Library | FDA Approved & Pharmacopeial Drug Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Y-27632 dihydrochloride | Chroman 1 | Belumosudil | Fasudil Hydrochloride | Thiazovivin | Narciclasine | Afuresertib | H-1152 dihydrochloride | GSK269962A | GSK429286A | Ripasudil | CCG-222740 | AT13148 | Y-33075 | LX7101 | HA-100 | GSK180736A | RKI-1447 | ROCK inhibitor-2 | SAR407899 | SR-3677 | Pentanoic acid | Verosudil | BDP5290 | CRT0066854 | Hydroxyfasudil
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文献和实验Preparation of Carboxypeptidase Y and Its Properties
while high efficiency habit in the scientific research. 【Requirement】 1. Use bread yeast as the original material to extract and condense carboxypeptidase Y, assay its biochemical properties. 2. Through gathering relevant published papers
用喹吖因（quinacrine）或喹吖因芥子（ quin- acrine mustard）染色，然后用荧光显微镜观察，在人的 Y染色体的长臂末端处能看到很强的荧光。在分裂期间的细胞核中也很容易看出这种荧光，因此把它叫做 Y染色质或 Y小体。由于 Y小体只有在男性中才能观察到，所以可用于人的性别鉴定。最近也已被奥林匹克运动会用于检查运动员的性别。然而这种现象只在人和大猩猩中观察到，在黑猩猩和猩猩等其他动物中， Y小体并不发出特别强的荧光。
每年到修改论文的时候，发现很多同学不懂图形和数据处理，出来的图形惨不忍睹。有的人想学没处学，有的根本不想学，最后的结果是研究生给本科生干活，老师给学生干活。所以有空的时候，想以这种方式写一点数据处理技术，给自己的未来减负。先从最简单的单X多Y图说起。 实验过程中经常遇到系列样品的表征数据，比如红外光谱、X-射线衍射等等，通常这些仪器测定的步长一致，也即X轴完全相同，这时候可以把系列数据绘制在一个图形中，图形的信息量丰富，也方便数据比较。例如这次本科论文中有一位同学的一组红外数据
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